This book develops a morphodynamical approach of spatial networks with a particular emphasis on infrastructure networks such as streets, roads and transportation networks (subway, train). The author presents the mathematical tools needed to characterize these structures and how they evolve in time. The book discusses the most important empirical results and stylized facts, and will present the most important models of spatial networks. The target audience primarily comprises research scientists interested in this rapidly evolving and highly interdisciplinary field, but the book may also be beneficial for graduate students interested in large networks.