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High Throughput Screening: Methods, Techniques and Applications

Editat de Mark Wigglesworth
en Limba Engleză Hardback – 25 feb 2020
High Throughput Screening (HTS) is one of several hit identification approaches that are part of a developing and evolving toolbox for the discovery of pharmaceutical start points. HTS remains one of the most successful approaches, and therefore an important foundation of drug discovery. In High Throughput Screening: Methods, Techniques and Applications, leading industrial and academic experts in screening and drug discovery explain key technologies and methods while demonstrating how they can be applied to successful hit identification. Describing both traditional and emerging methods in detail, this book provides an overview of these methods to the reader that will serve both those new to the field and expert scientists alike. High Throughput Screening: Methods, Techniques and Applications provides readers with an outline of key elements in the areas of assay development, detailed descriptions of a range of both biochemical and cell-based screening methodologies and strategies, as well as highlighting important steps in data analysis. By describing the basic principles of methods commonly used in HTS, High Throughput Screening: Methods, Techniques and Applications provides an illuminating introduction to HTS, capturing established good practice within the field, thereby imparting both the industrial and academic researcher with the knowledge required to work effectively in both today's and the hit identification laboratories of the future.
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Specificații

ISBN-13: 9781536172485
ISBN-10: 1536172480
Pagini: 490
Dimensiuni: 178 x 254 x 26 mm
Greutate: 0.81 kg
Editura: Nova Science Publishers Inc
Colecția Nova Science Publishers Inc
Locul publicării:United States

Cuprins

  • Preface
    • Assay Development for High Throughput Screening
    • Application of Fluorescence Technologies to High Throughput Screening Assays
    • Luminescence Technologies for High Throughput Compound Screening
    • Acoustic Mist Ionization Mass Spectrometry (AMI-MS) in High Throughput Screening
    • High Throughput Flow Cytometry: Principles, Practice and Prospects
    • Perspectives on High Content Imaging as an HTS Technology: Now and in the Future
    • Biophysical Hit Evaluation
    • CETSA in High Throughput Screening
    • Droplet-Based Microfluidics for High Throughput Screening
    • Encoded Library Technologies as Screening Platforms for Drug Discovery
    • Data Analysis in High Throughput Screening
    • The Application of Iterative Screening to Hit Identification
    • About the Editors
    • Index.
  •