The Global Economy that sustains the civilized world is destroying the biosphere. As a result, civilization, like the Titanic, is on a collision course with disaster. But changing course via the body politic appears to be well nigh impossible, given that much of the populace lives in denial. Why is that? And how did we get into such a fix?In this essay, biologists James Coffman and Donald Mikulecky argue that the reductionist model of the world developed by Western civilization misrepresents life, undermining our ability to regulate and adapt to the accelerating anthropogenic transformation of the world entrained by that very model. An alternative worldview is presented that better accounts for both the relational nature of living systems and the developmental phenomenology that constrains their evolution. Development of any complex system reinforces specific dependencies while eliminating alternatives, reducing the diversity that affords adaptive degrees of freedom: the more developed a system is, the less potential it has to change its way of being. Hence, in the evolution of life most species become extinct. This perspective reveals the limits that complexity places on knowledge and technology, bringing to light our hubristically dysfunctional relationship with the natural world and increasingly tenuous connection to reality. The inescapable conclusion is that, barring a cultural metamorphosis that breaks free of deeply entrenched mental frames that made us what we are, continued development of the Global Economy will lead inexorably to the collapse of civilization.