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Epigenome-Wide Association Studies: Methods and Protocols (Methods in Molecular Biology, nr. 2432)

Editat de Weihua Guan
Notă GoodReads:
en Limba Engleză Hardback – 04 May 2022
This volume details features of DNA methylation data, data processing pipelines, quality control measures, data normalization, and to discussions of statistical methods for data analysis, control of confounding and batch effects, and identification of differentially methylated regions. Chapters focus on microarray-based methylation measures and sequence-based measures. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary methodologies and software packages, step-by-step, readily reproducible analysis pipelines, and tips on troubleshooting and avoiding known pitfalls.
 
Authoritative and cutting-edge, Epigenome- Wide Association Studies: Methods and Protocols: aims to be a useful practical guide to researches to help further their study in this field. 
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Specificații

ISBN-13: 9781071619933
ISBN-10: 1071619934
Ilustrații: X, 229 p. 63 illus., 45 illus. in color.
Dimensiuni: 178 x 254 mm
Greutate: 0.64 kg
Ediția: 1st ed. 2022
Editura: Springer Us
Colecția Humana
Seria Methods in Molecular Biology

Locul publicării: New York, NY, United States

Cuprins

1. Quantification Methods for Methylation Levels in Illumina Arrays
Duchwan Ryu and Hao Shen
 
2. Evaluating Reliability of DNA Methylation Measurement
Rui Cao and Weihua Guan
 
3. Accurate measurement of DNA methylation: Challenges and Bias Correction
Eguzkine Ochoa, Verena Zuber, and Leonardo Bottolo
 
4. Using R for Cell-Type Composition Imputation in Epigenome-Wide Association Studies
Chong Wu
 
5. Cell Type-Specific Signal Analysis in Epigenome-Wide Association Studies
Charles E. Breeze
 
6. Controlling Batch Effect in Epigenome-Wide Association Study
Yale Jiang, Jianjiao Chen, and Wei Chen  
7. DNA methylation and Atopic Diseases
Yale Jiang, Erick Forno, and Wei Chen
  8. Meta-analysis for Epigenome-Wide Association Studies
Nan Wang and Shuilin Jin
 
9. Increase the Power of Epigenome-Wide Association Testing Using ICC-Based Hypothesis Weighting Bowen Cuia, Shuya Cuib, Jinyan Huanga, and Jun Chenc
 
10. A Review of High-dimensional Mediation Analyses in DNA Methylation Studies Haixiang Zhang, Lifang Hou, and Lei Liu
 
11. DNA Methylation Imputation across Platforms
Gang Li, Yun Li, and Guosheng Zhang  
12. Workflow to mine frequent DNA Co-Methylation Clusters in DNA Methylome Data
Jie Zhang and Kun Huang
  13. BCurve: Bayesian Curve Credible Bands Approach for Detection of  Differentially Methylated Regions
Chenggong Han and Shili Lin
 
14. Predicting chronological age from DNA methylation data: A machine learning approach for small datasets and limited predictors Anastasia Aliferi and David Ballard
 
15. Application of Correlation Pre-Filtering Neural Network to DNA Methylation Data: Biological Aging Prediction
Lechuan Li, Chonghao Zhang, Hannah Guan, and Yu Zhang
 
16. Differential Methylation Analysis for Bisulfite Sequencing (BS-seq) Data
Hao Feng, Karen Conneely, and Hao Wu

Textul de pe ultima copertă

This volume details features of DNA methylation data, data processing pipelines, quality control measures, data normalization, and to discussions of statistical methods for data analysis, control of confounding and batch effects, and identification of differentially methylated regions. Chapters focus on microarray-based methylation measures and sequence-based measures. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary methodologies and software packages, step-by-step, readily reproducible analysis pipelines, and tips on troubleshooting and avoiding known pitfalls.  
Authoritative and cutting-edge, Epigenome- Wide Association Studies: Methods and Protocols: aims to be a useful practical guide to researches to help further their study in this field. 

Caracteristici

Includes cutting-edge methods and protocols
Provides step-by-step detail essential for reproducible results
Contains key notes and implementation advice from the experts