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Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System de Nicholas J Brandon

Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System: Wiley Series in Drug Discovery and Development

Editat de Nicholas J Brandon, Anthony R West
en Limba Engleză Hardback – 5 mai 2014
This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed coverage. Therapeutic and drug discovery applications are covered for diseases including Alzheimer's, Parkinson's, schizophrenia, erectile dysfunction, and spinal cord injuries. There is also a chapter on drug discovery tools such as in vitro assays and X-ray structures for medicinal chemistry studies.
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Specificații

ISBN-13: 9780470566688
ISBN-10: 047056668X
Pagini: 408
Dimensiuni: 157 x 236 x 28 mm
Greutate: 0.7 kg
Ediția:New.
Editura: Wiley
Seria Wiley Series in Drug Discovery and Development

Locul publicării:Hoboken, United States

Public țintă

Academic and industrial researchers interested in drug discovery for neuroscience: medicinal chemists, pharmacologists, neuropharmacologists and biologists, biochemists, enzymologists, cell / molecular biologists, medical personnel, and clinicians

Notă biografică

NICHOLAS BRANDON works at AstraZeneca within the Neuroscience Innovative Medicines Group. He has spent his career in drug discovery with a strong interest in developing phosphodiesterase inhibitors for neuropsychiatric disorders and understanding the basic mechanisms of phosphodiesterase function. ANTHONY WEST is an Associate Professor in the Department of Neuroscience at Rosalind Franklin University. He has studied PDE function in the basal ganglia for over fifteen years, focusing on neurochemical and electrophysiological changes induced by PDE inhibitors in the healthy brain and in animal models of Parkinson's disease and Huntington's disease.

Descriere

This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed coverage.