This book constitutes the refereed proceedings of the 22nd International Conference on Computing and Combinatorics, COCOON 2016, held in Ho Chi Minh City, Vietnam, in August 2016. The 50 revised full papers papers presented in this book were carefully reviewed and selected from various submissions. The papers cover various topics including: Theory and Algorithms; Parameterized Complexity and Algorithms; Database and Data Structures; Computational Complexity; Approximation Algorithms; Cryptography; Network and Algorithms; Graph Theory and Algorithms; Computational Geometry; Scheduling Algorithms and Circuit Complexity; Computational Geometry and Computational Biology; and Logic, Algebra and Automata.