This book constitutes revised selected papers from the 25th Argentine Congress on Computer Science, CACIC 2019, held in Río Cuarto, Argentina, in October 2019. The 27 full papers presented in this volume were carefully reviewed and selected from a total of 185 submissions. They were organized in topical sections named: intelligent agents and systems; distributed and parallel processing; computer technology applied to education; graphic computation, images and visualization; software engineering; databases and data mining; hardware architectures, networks, and operating systems; innovation in software systems; signal processing and real-time systems; computer security; innovation in computer science education; and digital governance and smart cities.