Biological Toxins and Bioterrorism: Toxinology
Editat de P. Gopalakrishnakone, Mahdi Balali-Mood, Lyndon Llewellyn, Bal Ram Singhen Limba Engleză Electronic book text – 7 ian 2015
This reference work in theToxinologyhandbook series gathers together knowledge from around the globe about naturally inspired and manufactured biological weapons. The authors describe how they work; how authorities may detect their presence, prevent their use, and diagnose their impacts; and the means by which medical and paramedical professionals may treat victims. Also described are how they have been used to further our knowledge and what insights they have given us into evolutionary and physiological processes. Finally, it is also discussed how these toxins can be used as therapeutics and what the implications of such therapeutics are to their use as biothreat agents.
This volume provides a reference accessible to scientists, educators, and medical experts alike with an interest in biotoxins, focusing on the major toxins used as bioweapons. Regulatory agencies will also benefit from the information provided in this book. Some in the intended audience may need to understand how they elicit their effects and how we can defend ourselves against them. Others may be interested in the sometimes colorful histories that surround this subset of biotoxins that can be and, in some cases, have been used as weapons.
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Specificații
ISBN-13: 9789400758698
ISBN-10: 9400758693
Pagini: 550
Dimensiuni: 155 x 235 mm
Ediția:2015
Editura: SPRINGER NETHERLANDS
Colecția Springer
Seria Toxinology
Locul publicării:Dordrecht, Netherlands
ISBN-10: 9400758693
Pagini: 550
Dimensiuni: 155 x 235 mm
Ediția:2015
Editura: SPRINGER NETHERLANDS
Colecția Springer
Seria Toxinology
Locul publicării:Dordrecht, Netherlands
Public țintă
ResearchCuprins
Abrin
and
Immunoneutralization:
A
Review.-
Abrin:
A
Review.-
Aflatoxins.-
Aptamers
as
Antidotes
against
Toxins.-
Artificial
Resistance
using
Antitoxins
and
Anti-venoms.-
Basic
Chemistry
of
Toxins
Relevant
to
Vaccine,
Diagnostics,
and
Countermeasures.-
Bioactive
Peptides
Against
Bioterror
Agents.-
Biological
Toxin
Detection:
A
Review.-
Biology,
Ecology
and
Evolution
of
Receptor-Based
Toxin
Resistance.-
Biosecurity
and
Toxins.-
Botulinum
Toxins
Antidotes.-
Botulinum
Toxins:
A
Review.-
Cellular
Assays
for
Toxins.-
Challenges
in
Developing
Inhibitors
Against
Toxins.-
Cholera
Toxin.-
Counterfeit
Botulinum
Medical
Products
and
Risk
of
Bioterrorism.-
Decoy-Receptor-Like
Toxin-Binding
Proteins
and
Their
Potential
Role
in
Toxin
Resistance.-
Diagnostics
of
Botulism.-
Evolutionary
Traits
of
Toxins.-
Mycotoxins.-
Mycotoxins
II.-
Pheromones
and
Amphibian
Biology.-
Public
Health
Lab
Response
to
Potential
Toxin
Bioterrorism.-
Review
on
BTW:
Toxins
and
Contemporary
Bioterrorism.-
Ricin
as
Bioweapons.-
Ricin:
A
Review.-
Toxins
and
Food
Safety.-
Toxins
Detection.-
Toxins
of
GID
Relevance.-
The
Biology
of
Chemical
Signals
as
Toxins
and
in
Venoms.
Notă biografică
Prof
P.
Gopalakrishnakone
is
a
world
leader
in
the
characterization
of
the
structure
and
function
of
animal
and
plant
toxins
and
chemical
poisons,
which
contain
highly
specific
and
biologically
active
components.
He
has
contributed
significantly
to
the
body
of
knowledge
regarding
the
anatomy
of
snake
venom
glands
and
the
development
of
drug
candidates
from
animal
toxins.
Prof
Gopal
pioneered
the
development
of
the
NUS
Venom
and
Toxin
Research
Programme,
which
has
put
NUS
at
the
forefront
of
toxin
research
internationally. The
technology
platform
that
has
been
built
over
the
years
under
the
Venom
and
Toxin
Research
Programme,
coupled
with
its
extensive
library
of
protein
and
peptides,
has
enabled
Prof
Gopal
and
his
team
to
complete
the
discovery
process
of
lead
candidates
in
time
and
to
transfer
valuable
supplementary
information
to
the
next
discovery
steps
involving
profiling
and
optimization
of
lead
candidates. The
objective
is
to
characterize
the
venom
components
and
natural
toxins
at
a
molecular
level
and
identify
promising
compounds
amenable
to
the
development
of
novel
human
therapeutics.
Prof
Gopal’s
lab
has
identified
over
twenty
peptides
with
unique
medical
indications
from
venom-based
proteins
with
some
already
under
development
as
therapeutics.
His research
studies
includes
structure
function
studies
(toxin
detection,
biosensors,
antitoxins
and
neutralization
factors),
toxicogenomics
and
expression
studies, antimicrobial
peptides
from
venoms
and
toxins
and
PLA2
inhibitors
as
potential
drug
candidate
for
inflammatory
diseases. The
techniques
he
employs
include
quantum
dots
to
toxinology,
computational
biology,
microarrays
and
protein
chips.
He
has
patented
analgesic
peptide,
anti
inflammatory
peptide
as
well
as
anti
rheumatoid
arthritis
peptides.
He
is
exploring
various
possibilities
of
delivery
systems
for
these
peptides
to
target
sites
and
administration
of
these
peptides
orally,
transdermally,
ocular
and
injections.
Prof
Gopal
has
over
100
international
peer-reviewed
papers
in
venom
and
toxin
research,
drug
discovery,
biosensors,
and
toxinogenomics.
His
research
awards
include
the
Outstanding
University
Researcher
Award
from
the
National
University
of
Singapore
(1998);
Ministerial
Citation,
NSTB
Year
2000
Award
in
Singapore;
and
the
Research
Excellence
Award
from
the
Faculty
of
Medicine,
National
University
of
Singapore
(2003).
His
awards
in
teaching
include,
Faculty
Teaching
Excellence
Award
2003/4
&
NUS
Annual
Teaching
Excellence
Award
2003/4.
He
also
received
the
Faculty
Teaching
Excellence
Award
in
2009/10
and
the
Annual
Teaching
Excellence
Award,
NUS
FOR
2009/10.
He
is
the
President
of
International
Society
on
Toxinology
till
2012,
and
is
a
member
of
the
editorial
board
of
Toxicon,
the
official
journal
of
the
International
Society
on
Toxinology.
Mahdi Balali-Mood was a lecturer in clinical pharmacology and toxicology at Edinburgh University, UK, 1981-1982. He returned home during the Iraq-Iran war to assist the chemical casualties. He was promoted to associate professor in 1984 and full professor of Mashhad University in 1988. His other positions are as follows: founding member and president, Iranian Society of Toxicology (1989-2001), Asia-Pacific Association of Medical Toxicology (1994-2001), clinical toxicology adviser to WHO (1989 to date); member of many national and International organizations including Iranian Academy of Medical Sciences (1991 to date), World Academy of Sciences (1997 to date), Scientific Advisory Board and the working groups of Organization for Prohibition of Chemical Weapons (2004 to date); editor-in-chief,Scientific Journal of Birjand University of Medical Sciences(2002 to date); associate editor,Emerging Health Threats Journal, Forum of Emerging Health Threats, London, 2006 to 2012.
Bal Ram Singh, a former professor of biophysical chemistry and Henry Dreyfus Teacher-Scholar at University of Massachusetts Dartmouth, United States, and currently a professor and director of Botulinum Research Center, Institute of Advanced Sciences, has been conducting research for 27 years on the molecular mode of action of botulinum and tetanus neurotoxins, cranberry natural products, Ayurvedic and herbal products.
Lyndon Llewellyn is currently the program leader, data and technology innovation at the Australian Institute of Marine Science. He has a technical background in marine biology, biochemistry, and molecular pharmacology and has conducted numerous studies on both natural and artificial chemical toxicants on marine organisms using tools ranging from the molecular to mangrove trees, as well as biodiscovery for biotechnology. He has a particular expertise in organic marine toxins, including saxitoxin, the only marine toxin declared a chemical weapon, which can contaminate seafood, as well as marine and aquatic environments.
Mahdi Balali-Mood was a lecturer in clinical pharmacology and toxicology at Edinburgh University, UK, 1981-1982. He returned home during the Iraq-Iran war to assist the chemical casualties. He was promoted to associate professor in 1984 and full professor of Mashhad University in 1988. His other positions are as follows: founding member and president, Iranian Society of Toxicology (1989-2001), Asia-Pacific Association of Medical Toxicology (1994-2001), clinical toxicology adviser to WHO (1989 to date); member of many national and International organizations including Iranian Academy of Medical Sciences (1991 to date), World Academy of Sciences (1997 to date), Scientific Advisory Board and the working groups of Organization for Prohibition of Chemical Weapons (2004 to date); editor-in-chief,Scientific Journal of Birjand University of Medical Sciences(2002 to date); associate editor,Emerging Health Threats Journal, Forum of Emerging Health Threats, London, 2006 to 2012.
Bal Ram Singh, a former professor of biophysical chemistry and Henry Dreyfus Teacher-Scholar at University of Massachusetts Dartmouth, United States, and currently a professor and director of Botulinum Research Center, Institute of Advanced Sciences, has been conducting research for 27 years on the molecular mode of action of botulinum and tetanus neurotoxins, cranberry natural products, Ayurvedic and herbal products.
Lyndon Llewellyn is currently the program leader, data and technology innovation at the Australian Institute of Marine Science. He has a technical background in marine biology, biochemistry, and molecular pharmacology and has conducted numerous studies on both natural and artificial chemical toxicants on marine organisms using tools ranging from the molecular to mangrove trees, as well as biodiscovery for biotechnology. He has a particular expertise in organic marine toxins, including saxitoxin, the only marine toxin declared a chemical weapon, which can contaminate seafood, as well as marine and aquatic environments.
Caracteristici
Complete
and
comprehensive
overview
of
toxinology
Written by a very large team of experts from all around the world
Covers all areas of toxinology, including topics like bioterrorism, toxin evolution and toxin based drug development
Includes supplementary material: sn.pub/extras
Written by a very large team of experts from all around the world
Covers all areas of toxinology, including topics like bioterrorism, toxin evolution and toxin based drug development
Includes supplementary material: sn.pub/extras