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Bioinformatics and Functional Genomics

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en Limba Engleză Carte Hardback – 23 Oct 2015

The bestselling introduction to bioinformatics and genomics now in its third editionWidely received in its previous editions, Bioinformatics and Functional Genomics offers the most broad–based introduction to this explosive new discipline. Now in a thoroughly updated and expanded third edition, it continues to be the go–to source for students and professionals involved in biomedical research.

This book provides up–to–the–minute coverage of the fields of bioinformatics and genomics. Features new to this edition include:

 

 

 


  • Extensive revisions and a slight reorder of chapters for a more effective organization

 


  • A brand new chapter on next–generation sequencing

  • An expanded companion website, also updated as and when new information becomes available

  • Greater emphasis on a computational approach, with clear guidance of how software tools work and introductions to the use of command–line tools such as software for next–generation sequence analysis, the R programming language, and NCBI search utilities

The book is complemented by lavish illustrations and more than 500 figures and tables – many newly–created for the third edition to enhance clarity and understanding. Each chapter includes learning objectives, a problem set, pitfalls section, boxes explaining key techniques and mathematics/statistics principles, a summary, recommended reading, and a list of freely available software. Readers may visit a related Web page for supplemental information such as PowerPoints and audiovisual files of lectures, and videocasts of how to perform many basic operations: www.wiley.com/go/pevsnerbioinformatics.

Bioinformatics and Functional Genomics, Third Edition serves as an excellent single–source textbook for advanced undergraduate and beginning graduate–level courses in the biological sciences and computer sciences. It is also an indispensable resource for biologists in a broad variety of disciplines who use the tools of bioinformatics and genomics to study particular research problems; bioinformaticists and computer scientists who develop computer algorithms and databases; and medical researchers and clinicians who want to understand the genomic basis of viral, bacterial, parasitic, or other diseases.

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Specificații

ISBN-13: 9781118581780
ISBN-10: 1118581784
Pagini: 1160
Ilustrații: illustrations
Dimensiuni: 222 x 279 x 49 mm
Greutate: 3.05 kg
Ediția: 3rd Edition
Editura: Wiley
Locul publicării: Hoboken, United States

Public țintă

Primary Market: Undergraduate and graduate students in the biological sciences and computer sciences. The number of courses in these areas, particularly bioinformatics and genomics is growing rapidly. The fields of bioinformatics and genomics are both relatively new and extremely broad, so a variety of others will be interested in this book. Secondary Market: Anyone doing biomedical research, or biological or biomedical research, on any organism needs to use the tools of bioinformatics and thus is part of the secondary audience. The general orientation of the book is towards the biologist who wants to use the computer to further research.  The computer scientist who is interested in developing algorithms will find the book useful to learn what biological problems need to be solved.

Textul de pe ultima copertă

 

 

The bestselling introduction to bioinformatics and genomics now in its third editionWidely received in its previous editions, Bioinformatics and Functional Genomics offers the most broad–based introduction to this explosive new discipline. Now in a thoroughly updated and expanded third edition, it continues to be the go–to source for students and professionals involved in biomedical research.

This book provides up–to–the–minute coverage of the fields of bioinformatics and genomics. Features new to this edition include:

 

 

 


  • Extensive revisions and a slight reorder of chapters for a more effective organization

 


  • A brand new chapter on next–generation sequencing

  • An expanded companion website, also updated as and when new information becomes available

  • Greater emphasis on a computational approach, with clear guidance of how software tools work and introductions to the use of command–line tools such as software for next–generation sequence analysis, the R programming language, and NCBI search utilities

The book is complemented by lavish illustrations and more than 500 figures and tables – many newly–created for the third edition to enhance clarity and understanding. Each chapter includes learning objectives, a problem set, pitfalls section, boxes explaining key techniques and mathematics/statistics principles, a summary, recommended reading, and a list of freely available software. Readers may visit a related Web page for supplemental information such as PowerPoints and audiovisual files of lectures, and videocasts of how to perform many basic operations: www.wiley.com/go/pevsnerbioinformatics.

Bioinformatics and Functional Genomics, Third Edition serves as an excellent single–source textbook for advanced undergraduate and beginning graduate–level courses in the biological sciences and computer sciences. It is also an indispensable resource for biologists in a broad variety of disciplines who use the tools of bioinformatics and genomics to study particular research problems; bioinformaticists and computer scientists who develop computer algorithms and databases; and medical researchers and clinicians who want to understand the genomic basis of viral, bacterial, parasitic, or other diseases.


Cuprins

Part I Analyzing DNA RNA and Protein Sequences
1 Introduction 3
2 Access to Sequence Data and Related Information 19
3 Pairwise Sequence Alignment 69
4 Basic Local Alignment Search Tool (BLAST) 121
5 Advanced Database Searching 167
6 Multiple Sequence Alignment 205
7 Molecular Phylogeny and Evolution 245
Part II Genomewide Analysis of DNA RNA and Protein
8 DNA: The Eukaryotic Chromosome 307
9 Analysis of Next–Generation Sequence Data 377
10 Bioinformatic Approaches to Ribonucleic Acid (RNA) 433
11 Gene Expression: Microarray and RNA–seq Data Analysis 479
12 Protein Analysis and Proteomics 539
13 Protein Structure 589
14 Functional Genomics 635
Part III Genome Analysis
15 Genomes Across the Tree of Life 699
16 Completed Genomes: Viruses 755
17 Completed Genomes: Bacteria and Archaea 797
18 Eukaryotic Genomes: Fungi 847
19 Eukaryotic Genomes: From Parasites to Primates 887
20 Human Genome 957
21 Human Disease 1011
GLOSSARY 1075
Self–Test Quiz: Solutions 1103
Author Index 1105
Subject Index 1109


Notă biografică

Jonathan Pevsner, PhD, is a Professor in the Department of Neurology at Kennedy Krieger Institute, an internationally recognized institution dedicated to improving the lives of children with neurodevelopmental disorders. He holds a primary faculty appointment as Professor in the Department of Psychiatry and Behavioral Sciences (Johns Hopkins University School of Medicine). He holds joint or secondary appointments in the Department of Neuroscience, the Institute of Genetic Medicine, and the Division of Health Sciences Informatics (Johns Hopkins School of Medicine), and the Department of Molecular Microbiology and Immunology (Johns Hopkins Bloomberg School of Public Health). He has taught bioinformatics courses since 2000 at the Johns Hopkins School of Medicine, and was awarded Teacher of the Year honors by the Graduate Student Association in both 2001 and 2006, the Professors Award for Excellence in Teaching awarded by the medical faculty (2003), Teacher of the Year (Advanced Academic Programs, 2009), and Teaching Excellence Award in the Johns Hopkins Bloomberg School of Public Health (2011). In 2013 his lab used whole genome sequencing and reported a mutation that causes a rare disease, Sturge–Weber syndrome, as well as a commonly occurring port–wine stain birthmark.