This book constitutes the thoroughly refereed papers of the Second International Conference on Applied Informatics, ICAI 2020, held in Ota, Nigeria, in October 2020.  The 35 full papers were carefully reviewed and selected from 101 submissions. The papers are organized in topical sections on artificial intelligence; business process management; cloud computing; data analysis; decision systems; health care information systems; human-computer interaction; image processing; learning management systems; software design engineering.