Rachel Blum and Andy Landis are eight years old when they meet late one night in an ER waiting room. Born with a congenital heart defect, Rachel is a veteran of hospitals, and she's intrigued by the boy who shows up all alone with a broken arm. He tells her his name. She tells him a story. After Andy's taken back to the emergency room and Rachel's sent back to her bed, they think they'll never see each other again.

Rachel, the beloved, popular, and protected daughter of two doting parents, grows up wanting for nothing in a fancy Florida suburb. Andy grows up poor in Philadelphia with a single mom and a rare talent that will let him become one of the best runners of his generation.

Over the course of three decades, through high school and college, marriages and divorces, from the pinnacles of victory and the heartbreak of defeat, Andy and Rachel will find each other again and again, until they are finally given a chance to decide whether love can surmount difference and distance and if they've been running toward each other all along.