Vanadium isotope ratios (51V/50V) have potential to provide information about changes in past ocean oxygen contents. In particular, V isotopes may find utility in tracing variations at non-zero oxygen concentrations because the redox couple that controls V elemental and isotopic abundances in seawater (vanadate-vanadyl) appears to operate around 10M O2. This characteristic sets V isotopes apart from many other metal isotope redox proxies that require more reducing conditions to register significant changes in their isotope budgets. The oxygen abundance sensitivity range of V isotopes suggests that this paleoproxy could be particularly useful in tracing marine oxygenation changes throughout the Phanerozoic and potentially beyond.