In this issue of Surgical Pathology Clinics, guest editor Dr. Andrés M. Acosta brings his considerable expertise to the topic of Updates on Oncologic Genitourinary Pathology. Top experts help readers understand the relevance of new genomic, epigenomic, and transcriptomic data for classification of diverse genitourinary tumors. This issue also covers histopathologic correlates of molecular findings, biomarkers that represent current or potential predictors of clinical outcomes, and identifying biomarkers and molecular results that impact clinical management and guide treatment.