In this issue of Neurosurgery Clinics, guest editor Dr. Zoher Ghogawala brings his considerable expertise to the topic of Update on Lumbar Spondylolisthesis: Who, Why, and How. Top experts discuss key topics such as guidelines for the treatment of lumbar spondylolisthesis; natural history of lumbar spondylolisthesis; MIS options for lumbar spondylolisthesis; fusion as the optimal treatment for lumbar spondylolisthesis; lateral fusion for lumbar spondylolisthesis; and many more.