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Translational Neuroscience de Mark H. Tuszynski

Translational Neuroscience

Editat de Mark H. Tuszynski
en Limba Engleză Hardback – 3 iul 2025
The second edition of Translational Neuroscience offers wide-ranging and insightful perspectives on the effort to bring potentially revolutionary new classes of therapies to the clinic, thereby transforming the treatment of human nervous system disorders.
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Specificații

ISBN-13: 9783031893063
ISBN-10: 3031893069
Pagini: 552
Dimensiuni: 160 x 241 x 35 mm
Greutate: 0.98 kg
Ediția:Second Edition 2025
Editura: Springer

Cuprins

Introduction.- Gene Therapy of CNS Disorders using Recombinant AAV vectors.- NGF and BDNF Gene Therapy for Alzheimer’s Disease.- GDNF and AADC Gene Therapy for Parkinson’s Disease.- GAD Gene Therapy for Parkinson’s Disease.- Anti-sense Oligonucleotides for Amyotrophic Lateral Sclerosis.- Gene therapy for Inborn Errors of Metabolism: Batten Disease.- Gene Therapy for Spinal Cord Injury.- Gene Therapy for Epilepsy.- Translating Gene Therapy for Pain from Animal Studies to the Clinic.- Stem Cells for Parkinson’s Disease.- Could Stem Cells be used to treat or model Alzheimer’s Disease?.- Stem cells for Amyotrophic Lateral Sclerosis.- Stem cells for Multiple Sclerosis.- Cell Therapy for Pediatric Disorders of Glia.- Neural Stem Cells for Spinal Cord Injury.- Marrow-derived Mesenchymal Stromal Cells in the Treatment of Stroke.- Glioma Stem Cells.- Discovery of Potent Gamma Secretase Modulators for the Treatment of Alzheimer’s Disease.- Blocking the Nogo-A signalling pathway to promote regeneration and plasticity after spinal cord injury and stroke.- Intrinsic neuronal mechanisms in axon regeneration after spinal cord injury.- Voltage-gated ion channels as molecular targets for pain.- Rehabilitation-dependent neural plasticity after Spinal Cord Injury.- Neural Prostheses for Neurotrauma.- Why is Functional Electrical Stimulation Therapy Capable of Restoring Motor Function Following Severe Injury to the Central Nervous System? .- Deep Brain Stimulation for Neuropsychiatric Disorders.- Novel Interventions for Stroke: Nervous System Cooling.- Rehabilitation Strategies For Restorative Approaches After Stroke and Neurotrauma.- Bridging the Chasm between Scientific Discovery and a Pivotal Clinical Trial for a CNS Disorder: A Checklist.- Conclusion.

Notă biografică

Mark H. Tuszynski, MD, PhD, is a professor of neurosciences and founding director of the Translational Neuroscience Institute at the University of California – San Diego, and a neurologist at the Veterans Administration Medical Center in La Jolla, California. He received his undergraduate and MD degrees from the University of Minnesota in Minneapolis, completed neurology residency at Cornell University Medical Center / The New York Hospital, and subsequently received a PhD in neuroscience from the University of California – San Diego.  Dr. Tuszynski studies basic and translational aspects of neurodegenerative disorders and neurotrauma, and the biological basis of learning and memory.

Textul de pe ultima copertă

Translational Neuroscience offers a far-reaching and insightful series of perspectives on the effort to bring potentially revolutionary new classes of therapies to the clinic, thereby transforming the treatment of human nervous system disorders. Great advances in the fields of basic neuroscience, molecular biology, genomics, gene therapy, cell therapy, stem cell biology, information technology, neuro devices, rehabilitation and others over the last 20 years have generated unprecedented opportunities to treat heretofore untreatable disorders of the nervous system. This book provides a wide-ranging yet detailed sample of many of these efforts, together with the methods for pursuing clinical translation and assessing clinical outcomes. Among the topics covered are Alzheimer’s disease, Parkinson’s disease, stroke, multiple sclerosis, epilepsy, motor neuron disease, pain, inborn errors of metabolism, brain tumors, spinal cord injury, neuroprosthetics, rehabilitation and clinical trial design/consideration.
Translational Neuroscience is aimed at basic neuroscientists, translational neuroscientists and clinicians who seek to gain a perspective on the nature and promise of translational therapies in the current era. Both students and established professionals will benefit from the content.

Caracteristici

Offers a far-reaching and insightful series of perspectives on the effort to bring potentially revolutionary new classes of therapies to the clinic Provides neuroscientists, translational neuroscientists and clinicians a perspective on the nature and promise of translational therapies in the current era Features a wide-ranging yet detailed sample of progress made in the treatment of heretofore untreatable nervous system disorders