Trafficking Inside Cells: Pathways, Mechanisms and Regulation: Molecular Biology Intelligence Unit

Compartments and Pathways.- Overview of Intracellular Compartments and Trafficking Pathways.- How We Study Protein Transport.- The Golgi Apparatus.- The Endocytic Pathway.- Regulated Secretion.- Mechanisms.- Overview of Protein Trafficking Mechanisms.- Entry into the Endoplasmic Reticulum: Protein Translocation, Folding and Quality Control.- COP-Mediated Vesicle Transport.- Clathrin-Mediated Endocytosis.- Biogenesis of Dense-Core Secretory Granules.- Lipid-Dependent Membrane Remodelling in Protein Trafficking.- Carrier Motility.- Tethering Factors.- Intracellular Membrane Fusion.- Regulation and Coordination with Other Cellular Processes.- Regulation and Coordination of Intracellular Trafficking: An Overview.- Regulation of Protein Trafficking by GTP-Binding Proteins.- Posttranslational Control of Protein Trafficking in the Post-Golgi Secretory and Endocytic Pathway.- Actin Doesn’t Do the Locomotion: Secretion Drives Cell Polarization.- Intracellular Trafficking and Signaling: The Role of Endocytic Rab GTPase.- The Exocytic Pathway and Development.