40-year-old Lois Pritchard is a salaried partner - with Drs Robert Smith and Iwan James - and also works two days a week in the local Genitourinary Medicine (GUM) clinic. She is currently single, despite the attentions of her many admirers, and is, by her own admission, 'not very good with relationships'. When her estranged mother makes a dramatic appearance on the scene, Lois must look to something far more radical to sort out her personal life. Meanwhile, her patients' stories provide some welcome relief: a man who regrets the Pinocchio face he had tattooed on his genitals; a prescription drug addict who plans to sue his previous doctors for failing to refuse him the drugs he demanded; a health campaigner who vows to starve herself to death if her demands are not met; and a man who resorts to desperate measures after being driven mad by his neighbours' cats.