Innovations such as the Holistic Quality System and the Greening of Leadership are seemlessly integrated with concepts from Professional Psychology, Organizational Development, and Business Leadership. The Quality of the Humans themselves and of their leadership is key to the quality of everything else. Holistic Leadership is broad in nature and considers the integration of best practices from a variety of disciplines, including biobehavioral, technological, environmental and financial. The Human System is a comprised of a composite bio/psycho/social/spiritual being that is programmed by nature for optimal survival, effectivity, and efficiency. As the human system reaches the optimal state of homeostasis, losses are minimal, while gains are focused within the constraints imposed by nature, the culture they belong to, and the financial, human and technical systems they interact with.