The Herpesviruses (The Viruses) de Bernard Roizman

The Herpesviruses: Volume 3: The Viruses

Bernard Roizman

en Limba Engleză Paperback – 27 sep 2011

A great truth is a truth whose opposite. is also a great truth. Thomas Mann (Essay on Freud, 1937) This volume centers on pseudorabies (PR V), herpes simplex viruses 1 and 2 (HSV-1 and HSV-2), and human cytomegalovirus (CMV) and fulfills three objectives. The chapters on the epidemiology and latency of HSV, and on the glycoproteins specified by HSV and CMV, set the stage for the discussions of the immunobiology and pathogenesis of human herpesvirus infections in Volume 4. The epidemiology of HSV is the basis of our understanding of the spread and survival of this virus in the human populations. Central to the epidemiology of HSV and its pathogenesis in humans is the ability of the virus to remain in a latent state for the life of its host. The viral membrane glycoproteins are among the most interesting virion proteins, primarily because of their critical role in the initiation of infection. Since they are the surface membrane proteins of the virion and appear on the surface of productively infected cells, they are also the obvious if not the exclusive targets of the immune response. The chapters on the transforming potential of HSV and CMV, and on the role of HSV in human cancer, deal with challenging problems requiring rather different experimental tools.

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Cuprins

1 Epidemiology of Herpes Simplex Viruses.- I. Introduction.- II. Historical Background.- III. Descriptive Epidemiology.- IV. Recurrent Infection versus Reinfection with HSV.- V. Diseases of Epidemiologic Importance.- VI. HSV Infections and Cervical Carcinoma.- VII. Conclusion.- References.- 2 Individual HSV Transcripts: Characterization of Specific Genes.- I. Introduction.- II. HSV mRNA.- III. RNA Expressed in the Infected Cell.- IV. Detailed Analysis of Specific HSV Transcripts.- V. Specific HSV Genes.- VI. A Typical HSV-1 Transcription Unit.- VII. Generation of HSV Transcript ‘Families’.- References.- 3 Molecular Biology of Pseudorabies Virus.- I. Introduction.- II. Morphology.- III. Stability in the Presence of Physical and Chemical Agents.- IV. Virus Proteins.- V. Virus Genome.- VI. Virus Replication in Cell Culture.- VII. RNA Synthesis in PRV-Infected Cells.- VIII. Protein Synthesis in the Infected Cells.- IX. DNA Synthesis in PRV-Infected Cells.- X. Origins of DNA Replication.- XI. Mode of PRV DNA Replication.- XII. Maintenance of Sequence Identity of the Inverted Repeats.- XIII. Isomerization of the Virus Genome.- XIV. Process of Virion Assembly.- XV. Organization of the Genome of PRV.- XVI. Cellular Macromolecular Synthesis in the Infected Cells.- XVII. Sequence Homology between the Genomes of PRV and HSV.- XVIII. Aujeszky’s Disease.- References.- 4 Herpes Simplex Virus Latency.- I. Introduction.- II. The Site of Latent Infection.- III. Establishment of Latent Infection in Ganglia.- IV. Reactivation of the Latent Infection and the Production of Recurrent Disease.- References.- 5 Herpes Simplex Viruses and Their Roles in Human Cancer.- I. Introduction.- II. Definition of Risk.- III. Viral Genetic Information in Cancer Cells.- IV. Comments.- References.- 6Transforming Potential of Herpes Simplex Viruses and Human Cytomegalovirus.- I. Introduction.- II. Transforming Potential of HSV.- III. Transforming Potential of HCMV.- IV. Conclusion.- References.- 7 Glycoproteins Specified by Herpes Simplex Virus.- I. Introduction.- II. The HSV Glycoproteins and Their Structural Genes.- III. Synthesis and Processing of the Glycoproteins.- IV. Activities and Roles of the Glycoproteins.- V. Appendix.- References.- 8 Processing of the Oligosaccharide Chains of Herpes Simplex Virus Type 1 Glycoproteins.- I. Introduction.- II. HSV-1 Glycoproteins.- III. Biosynthesis and Characterization of the Oligosaccharide Chains of HSV-1 Glycoproteins.- IV. Relationship between Glyean Structure and Expression of HSV-1 Functions.- References.- 9 Glycoproteins Specified by Human Cytomegalovirus.- I. Introduction.- II. CMV Glycoproteins f.- III. Characterization of CMV Glycoproteins with Monoclonal Antibodies.- IV. Mapping CMV Genes.- V. Synthesis and Processing of CMV gA.- References.