In this issue of Hand Clinics, guest editors Drs. Alfred P. Yoon and Kevin C. Chung bring their considerable expertise to the topic of The Essence of Artificial Intelligence in Healthcare. Artificial Intelligence (AI) in healthcare represents a revolutionary shift in how medical professionals approach diagnosis, treatment, and patient care. In this issue, top experts cover new and up-and-coming subfields of artificial intelligence in a digestible manner, as well as their potential applications in medicine.