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The Developing Genome: An Introduction to Behavioral Epigenetics de David S. Moore

The Developing Genome: An Introduction to Behavioral Epigenetics

Autor David S. Moore
en Limba Engleză Paperback – 11 mai 2017

Găsim în această carte un răspuns clinic și sistematic la o întrebare fundamentală: de ce dezvoltăm anumite trăsături psihologice și fizice în detrimentul altora? Pornind de la scenarii concrete despre cum stilul de parenting sau expunerea la toxinele din mediu „se strecoară sub piele”, The Developing Genome demonstrează că genele cu care ne naștem nu sunt un verdict final. Ne-a atras atenția modul în care David S. Moore explică activitatea genetică nu ca pe un set fix de instrucțiuni, ci ca pe un proces dinamic, influențat direct de experiențele noastre de viață.

Abordarea este una riguroasă, specifică psihologiei clinice, investigând cum mecanismele epigenetice pot altera tratamentul unor afecțiuni complexe precum schizofrenia sau stresul post-traumatic. Autorul reușește să traducă procese moleculare dificile într-un limbaj accesibil, fără a sacrifica precizia științifică. Clinicienii care folosesc Epigenetics and Behavior de F. Scott Hall ca referință vor găsi aici o completare esențială, deoarece Moore pune un accent mai mare pe dezvoltarea timpurie și pe plasticitatea sistemului nervos în contextul interacțiunii dintre mediu și genom.

Această lucrare reprezintă o evoluție naturală față de volumul său anterior, The Dependent Gene, unde Moore a început deconstrucția determinismului genetic. Dacă în lucrările sale despre statistică autorul pune accent pe interpretarea corectă a datelor, în The Developing Genome el aplică aceeași rigoare pentru a reevalua teoria evoluționistă a secolului XX. Reținem un ton echilibrat, care nu promite soluții magice, ci oferă un cadru științific solid pentru înțelegerea naturii umane prin prisma epigeneticii comportamentale.

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Specificații

ISBN-13: 9780190675653
ISBN-10: 0190675659
Pagini: 320
Ilustrații: b/w illus.
Dimensiuni: 155 x 239 x 20 mm
Greutate: 0.48 kg
Editura: OUP OXFORD
Colecția OUP Oxford
Locul publicării:Oxford, United Kingdom

De ce să citești această carte

Această carte este esențială pentru profesioniștii din domeniul sănătății mintale și pentru studenții la psihologie care doresc să înțeleagă biologia din spatele comportamentului uman. Cititorul câștigă o perspectivă modernă asupra modului în care mediul modelează expresia genelor, oferind un argument științific împotriva fatalismului genetic. Este un ghid clar despre cum intervențiile terapeutice și stilul de viață pot influența funcționarea biologică profundă.

Despre autor

David S. Moore, Ph.D., este profesor de psihologie la Pitzer College și Claremont Graduate University, având un doctorat obținut la Harvard University. Experiența sa vastă în psihologia dezvoltării și neuroștiințele cognitive a fost modelată de cercetările efectuate asupra sugarilor, unde a observat interacțiunea complexă dintre factorii ereditari și mediu. Moore este un expert recunoscut în domeniul epigeneticii comportamentale, integrând date din biologie și psihologie pentru a redefini conceptele tradiționale de dezvoltare umană. Pe lângă lucrările sale teoretice despre genom, este și un autor respectat în domeniul statisticii aplicate.

Descriere

Why do we grow up to look, act, and feel as we do? Through most of the twentieth century, scientists and laypeople answered this question by referring to two factors alone: our experiences and our genes. But recent discoveries about how genes work have revealed a new way to understand the developmental origins of our characteristics. These discoveries have emerged from the new science of behavioral epigenetics--and just as the whole world has now heard of DNA, "epigenetics" will be a household word in the near future. Behavioral epigenetics is important because it explains how our experiences get under our skin and influence the activity of our genes. Because of breakthroughs in this field, we now know that the genes we're born with don't determine if we'll end up easily stressed, likely to fall ill with cancer, or possessed of a powerful intellect. Instead, what matters is what our genes do. And because research in behavioral epigenetics has shown that our experiences influence how our genes function, this work has changed how scientists think about nature, nurture, and human development. Diets, environmental toxins, parenting styles, and other environmental factors all influence genetic activity through epigenetic mechanisms; this discovery has the potential to alter how doctors treat diseases, and to change how mental health professionals treat conditions from schizophrenia to post-traumatic stress disorder. These advances could also force a reworking of the theory of evolution that dominated twentieth-century biology, and even change how we think about human nature itself. In spite of the importance of this research, behavioral epigenetics is still relatively unknown to non-biologists. The Developing Genome is an introduction to this exciting new discipline; it will allow readers without a background in biology to learn about this work and its revolutionary implications.

Recenzii

Winner of the 2016 William James Book Award
Winner of the 2016 Eleanor Maccoby Book Award
David Moore's description of the complex discoveries in epigenetics is a tour de force-it allows all readers to appreciate the significance of these unexpected phenomena. The Developing Genome is required reading for all who wonder about the power of genes."
Epigenetics is one of the hottest topics in biology these days, and that certainly makes sense-it helps explain on a nuts-and-bolts level precisely how experience, especially early in life, leaves long-lasting effects on our bodies and our behaviors. Not surprisingly, it's also a complex subject to understand, and is vulnerable to hype and inflated promises. There's no one better than David Moore to write a book like this-he knows the field inside out and writes about it in a way that is insightful, appropriately skeptical at points, and utterly clear and accessible to the interested non-scientist. This is a terrific book."
Every dogma has its day, and the once-vaunted central dogma of molecular biology has seen better ones. A steady stream of surprising findings emerging from the rapidly growing field of behavioral epigenetics is showing us how our DNA does not legislate from above, but is rather a participant in a highly interactive developmental system. It is from this system that our behavior and psychology emerge. In his wonderfully informative and accessible new book, David Moore proves himself a skillful guide to this very complicated and vast new field. For readers hoping to understand what all the excitement is about without drowning in a sea of jargon, they need look no further."
Reading David Moore's explanation of epigenetics is relevant for anyone who is interested in health and behavior as an aid in making appropriate life decisions, or from an academic perspective. This authoritative, intriguing, practical, and wise book helps steer us away from the tradition of assuming that genes are deterministic, and towards a better understanding of how life experiences can alter the genomic heritage that all parents share with their children."
[The Developing Genome] show the limitation of the blueprint metaphor of genomes for something so intricate, complex, multilayered and dynamic. [It] underscore[s] the risks of taking metaphors too literally, not just in undermining popular understanding of science, but also in trammelling scientific enquiry. They are for anyone interested in how new discoveries and controversies will transform our understanding of biology and of ourselves. Behavioural epigenetics is a controversial field, with critics arguing that many of its findings are little more than correlation and conjecture. Moore is suitably sceptical without shying away from the more contentious areas." -Claire Ainsworth, New Scientist
Moore's book joins Jablonka and Lamb's text as a new standard in epigenetics literature. It is a compulsively readable account of one of the most vibrant areas in science that is well-researched, well-written, and thought-provoking from beginning to end. For both general readers and interdisciplinary scholars, The Developing Genome can be considered the logical starting point to acquaint themselves with a field that is quickly becoming impossible to ignore."

Notă biografică

David S. Moore is a professor of psychology at Pitzer College and Claremont Graduate University in southern California. He received his PhD in developmental and biological psychology from Harvard University. A developmental cognitive neuroscientist with expertise in infant cognition, Moore explores the contributions of genetic, environmental, and epigenetic factors to human development. His book The Dependent Gene was widely adopted for use in undergraduate education and was nominated for the Cognitive Development Society's Best Authored Volume award.