Targeting DNA Repair Mechanisms, Tumor Genetics, and Signaling Pathways: Synergistic Approaches in Gastrointestinal Cancer Treatment
Editat de Ganji Purnachandra Nagaraju, Bassel F-El-Rayesen Limba Engleză Paperback – mai 2026
Featuring real-world case studies and insights from leading experts, the book bridges the gap between basic research and clinical application. For an academic audience, this resource promotes a holistic understanding of GI cancer biology, addresses treatment resistance, and fosters collaboration among researchers and clinicians, ultimately improving patient outcomes in this rapidly evolving field.
- Provides a thorough examination of the complex mechanisms underlying gastrointestinal cancers, including DNA repair pathways, tumor genetics, and cellular signaling
- Bridges the gap between basic research findings and their clinical applications, featuring real-world case studies and expert insights
- Highlights novel therapeutic approaches, including combination therapies and personalized medicine
- Addresses treatment resistance and promotes collaborative strategies
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Specificații
ISBN-13: 9780443439766
ISBN-10: 0443439761
Pagini: 220
Dimensiuni: 191 x 235 mm
Editura: ELSEVIER SCIENCE
ISBN-10: 0443439761
Pagini: 220
Dimensiuni: 191 x 235 mm
Editura: ELSEVIER SCIENCE
Cuprins
1. Introduction to Gastrointestinal Cancers: An Overview of Current Challenges
2. Understanding DNA Repair Mechanisms: The Key Players in Genomic Stability
3. The Genetic Landscape of Gastrointestinal Tumors: Key Alterations and Pathways
4. The Role of Signaling Pathways in Tumorigenesis
5. The Role of DNA Damage Response in Cancer Progression
6. Synergistic Approaches in GI Cancer Therapy: Concepts and Strategies
7. Targeting DNA Repair and Signaling Pathways: A Novel Paradigm in Gastrointestinal Cancer Treatment
8. Inhibiting Homologous Recombination: Therapeutic Implications in GI Cancers
9. The Role of PARP Inhibitors in Enhancing Chemotherapy Efficacy
10. Exploiting the Synthetic Lethality Concept in Gastrointestinal Tumors
11. Combination Therapies: Chemotherapy and DNA Repair Inhibition in GI Cancers
12. Immunotherapy and DNA Repair: A Dual Approach to Combat GI Cancers
13. Radiation Therapy: Targeting DNA Repair Mechanisms for Enhanced Outcomes
14. Emerging Biomarkers: Predicting Response to DNA Repair and Signaling Targeting Therapies
15. Clinical Trials: Evidence for Synergistic Approaches in GI Cancer Treatment
16. Future Directions: Novel Targets and Strategies in DNA Repair, Signaling for GI Cancers
17. Integrating Genomics with Immunotherapy for GI Cancers: A Synergistic Approach
18. Conclusion: Integrating Synergistic Approaches for Personalized GI Cancer Treatment
2. Understanding DNA Repair Mechanisms: The Key Players in Genomic Stability
3. The Genetic Landscape of Gastrointestinal Tumors: Key Alterations and Pathways
4. The Role of Signaling Pathways in Tumorigenesis
5. The Role of DNA Damage Response in Cancer Progression
6. Synergistic Approaches in GI Cancer Therapy: Concepts and Strategies
7. Targeting DNA Repair and Signaling Pathways: A Novel Paradigm in Gastrointestinal Cancer Treatment
8. Inhibiting Homologous Recombination: Therapeutic Implications in GI Cancers
9. The Role of PARP Inhibitors in Enhancing Chemotherapy Efficacy
10. Exploiting the Synthetic Lethality Concept in Gastrointestinal Tumors
11. Combination Therapies: Chemotherapy and DNA Repair Inhibition in GI Cancers
12. Immunotherapy and DNA Repair: A Dual Approach to Combat GI Cancers
13. Radiation Therapy: Targeting DNA Repair Mechanisms for Enhanced Outcomes
14. Emerging Biomarkers: Predicting Response to DNA Repair and Signaling Targeting Therapies
15. Clinical Trials: Evidence for Synergistic Approaches in GI Cancer Treatment
16. Future Directions: Novel Targets and Strategies in DNA Repair, Signaling for GI Cancers
17. Integrating Genomics with Immunotherapy for GI Cancers: A Synergistic Approach
18. Conclusion: Integrating Synergistic Approaches for Personalized GI Cancer Treatment