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Stroke Genetics de Pankaj Sharma

Stroke Genetics

Editat de Pankaj Sharma, James F. Meschia
en Limba Engleză Hardback – 26 iun 2017
This revised, expanded second edition updates the reader on this fast moving field as well providing an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genomewide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed.Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics.
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Specificații

ISBN-13: 9783319562087
ISBN-10: 3319562088
Pagini: 431
Ilustrații: XII, 431 p. 39 illus., 26 illus. in color.
Dimensiuni: 155 x 235 mm
Greutate: 0.89 kg
Ediția:2nd ed. 2017
Editura: Springer International Publishing
Colecția Springer
Locul publicării:Cham, Switzerland

Cuprins

Introduction.- Familial stroke epidemiology.- Association study results.- GWAS.- Aneurysms/carvernous/AVM.- ICH/amyloid/microbleeds.- CADASIL.- Fabry.- MELAS.- Sickle.- Other monogenic.- White matter disease.- Carotid atherosclerosis.- Dissection.- Pharmacogenomics.- Non-Caucasian stroke genetics.- Small vessel disease.- Genetics of neuroimaging in stroke.- Cerebrovenous thrombosis.- Ethics.

Notă biografică

Pankaj Sharma, MD, PhD, FRCP
Reader & Consultant Neurologist
Imperial College London & Hammersmith Hospitals
London, UK
James F. Meschia, MD
Chair, Department of Neurology
Mayo Clinic
Jacksonville, Florida, USA

Textul de pe ultima copertă

This revised, expanded second edition updates the reader on this fast moving field as well providing an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genomewide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed.
Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics.

Caracteristici

Discusses important and novel results from large datasets, as genetics has continued to advance at an unprecedented rate since the first edition Includes new chapters on nonCaucasian stroke, advanced imaging and cerebral venous thrombosis- Written by international experts who have been intimately involved in unraveling the genetic etiology of stroke Includes supplementary material: sn.pub/extras

Recenzii

From the reviews:
“This text reviews genetics of cerebrovascular diseases … . It covers the pathophysiology of occlusive small vessel disease and arteriopathies. It covers Fabry’s Disease, Amyloidosis, MELAS, etc., etc. It covers the imaging, pathophysiology, treatment, and complications for ischemia and hemorrhaging. I recommend this text for neurosurgeons, neurologists, physiologists, genetic investigators, and those with an interest in vascular diseases affecting the cerebrum.” (Joseph J. Grenier, Amazon.com, May, 2014)