This detailed volume covers diverse aspects of stem cell research and exemplifies some of the developments and improvements in the field. The book explores how to regulate and manipulate stem cells appropriately in vitro, allowing for the generation of very early embryo-like structures, known as blastoids, opening up opportunities for analyzing and delineating the very early steps in embryo development under controlled in vitro conditions. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Stem Cell-Based Human Embryo Models: Methods and Protocols serves as an ideal guide for researchers looking to drive rapid innovations in the study of early embryonic development.