In this issue of Neurosurgery Clinics, guest editor Dr. Vinil Shah brings his considerable expertise to the topic of Spine Imaging and Intervention. Top experts discuss key issues such as the anatomy, technique, safety, and efficacy of image-guided epidural access; imaging of discogenic and vertebrogenic pain; fat-suppressed MR and molecular imaging of spinal pain generators; spinal cerebrospinal fluid leak localization with digital subtraction myelography; and many more.