The process in which a sample of skin tissue is removed, processed, and examined with the help of a microscope is referred to as skin biopsy. This book is a compilation of selected topics related to the methods and applications of skin biopsy in diagnosing skin diseases. There have been several publications providing overview or interpretation of skin biopsy theories in a number of distinct skin diseases. However, only few of these books discuss in detail about perfecting skin biopsy methodologies. This book is an effort towards bridging this gap. It emphasizes on making use of current techniques to treat skin diseases in humans. It also includes few topics on skin biopsy in animals. This facilitates the readers in being well-versed about the interrelations between various sub-domains of skin biopsy. The book deals with all aspects of the procedure of skin biopsy and aims to improve biopsy outcomes for patients.