Little Italy, New York City. 1920. An 8-year-old boy and girl become best-friends. As teenagers, their friendship turns to love. By the age of 20, they are one -- soulmates, sharing their hopes, dreams, and wishes. Despite these unconditional pledges, life gets in the way during the next 79 years. He becomes a famous musician, battles substance abuse, has a nervous breakdown, and marries two other women (one commits suicide). The girl lives a roller coaster of her own. She marries a businessman who dies in his sleep at 60, leaving a tangled web of bankruptcy and IRS demands for millions in back taxes. Despite all the broken promises and shattered dreams, the boy and girl find proper ways to stay connected until they die. Fittingly, they are buried in the same cemetery, not far from each other.