Cyber-Physical Systems (CPS) are hybrid networked cyber and engineered physical elements co- designed to create adaptive and predictive systems for enhanced performance.1, 2 These smart systems present a key opportunity to create a competitive advantage for U.S. industrial innova- tion and to improve the performance and reliability of new and existing systems. From smart manufacturing and the electric smart grid, to smart structures and transportation systems, CPS will pervasively impact the economy and society.