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OPLL: Ossification of the Posterior Longitudinal Ligament de Atsushi Okawa

OPLL: Ossification of the Posterior Longitudinal Ligament

Editat de Atsushi Okawa, Morio Matsumoto, Motoki Iwasaki, Yoshiharu Kawaguchi
en Limba Engleză Paperback – 16 mai 2021

Gestionarea deficitelor neurologice severe cauzate de compresia măduvei spinării reprezintă una dintre cele mai mari provocări în chirurgia spinală, mai ales când etiologia implică transformarea ligamentelor în țesut osos. În volumul OPLL, coordonat de Atsushi Okawa și echipa sa, găsim o analiză clinică și științifică de o profunzime rară asupra osificării ligamentului longitudinal posterior. Această a treia ediție survine într-un moment critic, integrând progresele tehnologice și clinice majore apărute din 2006 până în prezent.

Considerăm că forța acestui tratat rezidă în capacitatea de a uni cercetarea fundamentală cu practica chirurgicală. Structura este riguros organizată în secțiuni care pornesc de la istoric și epidemiologie, trec prin genetica moleculară — unde sunt explorate celulele stem mezenchimale și tehnologia iPS — și culminează cu protocoalele de diagnostic. Cartea nu se limitează doar la OPLL, ci extinde spectrul către osificarea ligamentului galben (OLF), oferind o perspectivă holistică asupra condițiilor hiperostotice ale coloanei.

Credem că acest manual completează esențial lucrarea Cervical Spondylotic Myelopathy and Ossification of Posterior Longitudinal Ligament de Mehmet Zileli. În timp ce volumul lui Zileli se concentrează pe consensul comitetului WFNS și tehnici chirurgicale, ediția de față aduce în plus detalii despre patogeneza moleculară și analize de metabolomică, oferind contextul biologic necesar pentru înțelegerea progresiei bolii. Ritmul expunerii este unul academic, cu o densitate informațională care reflectă experiența vastă a școlii japoneze de ortopedie în acest domeniu specific. Este o resursă indispensabilă pentru înțelegerea mecanismelor de „ossification of the ligamentum flavum”, facilitând decizii terapeutice bazate pe dovezi actualizate.

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Specificații

ISBN-13: 9789811538575
ISBN-10: 9811538573
Pagini: 278
Ilustrații: X, 278 p. 138 illus., 61 illus. in color.
Dimensiuni: 178 x 254 mm
Greutate: 0.59 kg
Ediția:3rd ed. 2020
Editura: Springer Nature Singapore
Colecția Springer
Locul publicării:Singapore, Singapore

De ce să citești această carte

Recomandăm această ediție a treia chirurgilor ortopezi și neurochirurgilor care tratează mielopatii complexe. Cititorul câștigă acces la cele mai noi date despre genetica și istoria naturală a OPLL, fiind singura resursă care integrează tehnologia celulelor stem și metabolomica în diagnosticul spinal. Este un instrument de referință pentru a diferenția precis între diversele forme de hiperostoză vertebrală și pentru a anticipa evoluția neurologică a pacienților.

Despre autor

Atsushi Okawa, Morio Matsumoto, Motoki Iwasaki și Yoshiharu Kawaguchi sunt autorități de renume mondial în chirurgia coloanei vertebrale, activând în instituții academice de elită din Japonia. Expertiza lor colectivă acoperă întreg spectrul patologiilor spinale, de la cercetarea de laborator asupra celulelor stem până la tehnici chirurgicale de avangardă. Aceștia au contribuit decisiv la literatura medicală internațională prin studii pe termen lung privind istoria naturală a osificării ligamentelor, transformând acest domeniu dintr-o nișă regională într-o prioritate globală a ortopediei moderne.

Descriere scurtă

This book brings together information on all aspects of ossification of the posterior longitudinal ligament (OPLL), a hyperostotic condition of the spine that can cause severe neurological deficits. Since the second edition of this book was published in 2006, there have been tremendous advances in the field, and this third edition provides updated information on the disease’s epidemiology, diagnosis and treatment, while also addressing ossification of the ligamentum flavum (OLF) and diffuse idiopathic spinal hyperostosis. As such, it offers a valuable resource for all those who want to gain a deeper understanding of OPLL/OLF and those involved in making decisions about its treatment.

Cuprins

Part 1 Introduction.- 1 History of research.- Part 2 Epidemiology.- 2 An Overview of Epidemiology and Genetics.- 3 OPLL: Disease entity, prevalence, literature research, and growth.- 4 Natural History of Ossification of the Posterior Longitudinal Ligament (OPLL).- Part 3 Pathology & Pathogenesis.- 5 Overview of Recent Basic Researches on OPLL and OLF.- 6 Histopathological Features of Ossification of the Posterior Longitudinal Ligament.- 7 Ectopic Ossification of Human Spinal Ligaments Caused by Mesenchymal Stem Cell Abnormalities.- 8 A Short History of Genetic Study of OPLL.- 9 Overview of possible roles of OPLL-associated genes in OPLL development.- 10 Application of iPS cell technology for OPLL.- 11 Mechanisms underlying OPLL development in Tiptoe Walking (ttw) Mice.- 12 In vivo tracing of neural tracts in tip-toe walking Yoshimura mice by diffusion tensor tractography.- 13 Metabolomics analysis in OPLL patients.- Part 4 Diagnosis.- 14 Diagnosis of OPLL and OLF: overview.- 15Clinical manifestation of cervical OPLL.- 16 Three-dimensional imaging of cervical ossification of the posterior longitudinal ligament.- 17 Clinical manifestations of thoracic ossification of the posterior longitudinal ligament (OPLL) and ossification of the ligament flavum (OLF).- 18 Evaluation of distribution patterns of spinal ligament ossification using whole-spine computed tomography in patients with cervical ossification of the posterior longitudinal ligament.- 19 Diagnostic imaging of thoracic OPLL and OLF.- 20 Biomechanics of the spinal cord compression due to cervical ossification of the posterior longitudinal ligament.- Part 5 Treatment.- 21 Surgical Indications and Choice of Surgical Procedure for Cervical Ossification of the Longitudinal Ligament.- 22 Overview of Laminoplasty.- 23 Open-door Laminoplasty for Cervical OPLL: Technique, Long-term Results, and Complications.- 24 Double-door Laminoplasty for Cervical OPLL : Technique, Complications and Long-term Results.- 25 Posterior Decompression and Fusion for Cervical OPLL: Indication and Technique.- 26 Anterior Cervical Decompression for Cervical OPLL: Technique, Complications and Long-term Results.- 27 Surgical Indications and Choice of Surgical Procedure for Thoracic OPLL.- 28 Posterior decompression and fusion for thoracic OPLL: surgical techniques, outcomes, timing and complications.- 29 Anterior Decompression and Fusion for Thoracic OPLL: Transthoracic and Transsternal Approaches.- 30 Circumferential Decompression Through Posterior Approach for Thoracic OPLL: Technique and Complications.- 31 Surgery for ossification of the ligamentum flavum: posterior decompression with or without fusion.- 32 Computer-Aided Surgery for Ossification of the Spinal Ligaments.- 33 Surgical Treatment of Thoracic Ossification of the Posterior Longitudinal Ligament: Intraoperative Spinal Cord Monitoring.- 34 Intraoperative ultrasonography for patients with ossification of the posterior longitudinal ligament.

Notă biografică

Atsushi Okawa, MD and PhD, is a Professor and Chairman of Orthopaedic and Spinal Surgery at Tokyo Medical and Dental University. He also serves as a director of the university. He has previously served as Vice-president of the Japanese Orthopaedic Association, and as chief researcher in a study group on the ossification of the spinal ligaments, supported by a Japanese Health Labor Sciences Research Grant for six years until 2019. His chief areas of expertise are anterior corpectomy and fusion for OPLL and research into spinal cord monitoring. He has published over 100 papers in these areas.
Morio Matsumoto, MD and PhD, is a Professor and Chairman of Orthopedic Surgery at Keio University. He also serves as President of the Japanese Orthopaedic Association. His research interests include genetic studies on ossification of the posterior longitudinal ligament and idiopathic and congenital scoliosis, as well as clinical studies on various spinal disorders. He has published over 400peer-reviewed articles in the field of orthopedics.
Motoki Iwasaki is Vice-President of Osaka Rosai Hospital and a Clinical Professor at Osaka University’s Graduate School of Medicine. He has previously served as a visiting assistant professor at the Department of Orthopaedic Surgery, UCSF (1995-1997). His main research interests are in OPLL and spinal deformities. He has published over 250 papers and over 60 books. He also serves as an editor for Spine Surgery and Related Research, and for Journal of Orthopaedic Science. He has been honored e.g. with an Academic Encouragement Award (JOA, 1994), New Investigators Recognition Award (ORS, 1997), and Clinical Research Award (CSRS, 2001 & 2003).
Yoshiharu Kawaguchi is a Professor and Chairman of the Department of Orthopaedic Surgery, University of Toyama. He also serves as Educational Chair of Orthopaedic Surgery, AOSpine Asia Pacific region and has previously chaired the International Committee of the Japanese Orthopaedic Association (JOA). His research interests include spinal surgery and the pathology of spinal diseases, including ossification of the spinal ligaments. He has published over 100 papers and eight books. He is a chief editor of the Journal of Spine Research, the official journal of the Japanese Society of Spine Research (JSSR); a deputy editor of Spine Surgery Related Research, the official English-language journal of the JSSR; and a deputy editor of Global Spine Journal, the official journal of AOSpine. He has been honored with various awards, including a JOA basic research award (1996) and JOA clinical research award (2004).

Caracteristici

Provides fresh insights on OPLL Covers a wide range topics from epidemiology to treatment Written by leading experts on ossification of the spinal ligaments