A mutation resulting in a single base nucleotide being replaced by a genetic nucleotide is referred to as point mutation. This text sheds light on the marks left behind in chromosomes by the influencers that propel the DNA code evolution in the form of DNA nucleotide replacements. Since the genetic code is crucial in prior determination of the molecular foundation of existence, it can affect any facet of biology. Incidentally, it is concerned primarily with the evolution of germs and their human hosts. The unique distinction of this text is the rapid pace at which DNA information has been gathered over the past few years and how advancements in this exciting field of study are currently being applied in the medical world.