Nimodipine: Pharmacological and Clinical Results in Cerebral Ischemia

Session I. Pharmacology.- Pharmacology Overview: Nimodipine in CNS-Indications.- Changes in Intracellular Free Calcium During Cerebral Ischemia and the Effects of Nimodipine on Calcium and Histological Damage.- Experimental Models of Focal Ischemia: Results with Nimodipine.- The Effect of Nimodipine Pretreatment on Focal Cerebral Ischemia in the Hypertensive Rat.- Cardiac Arrest, Stroke, Subarachnoid Hemorrhage, and Severe Head Injury: What do They Have in Common?.- Dihydropyridines Attenuate Slow Excitatory Amino Acid Neurotoxicity.- Session II. Subarachnoid Hemorrhage.- The Pathophysiology of Arterial Narrowing and Delayed Ischemic Deficit After Subarachnoid Hemorrhage.- Advances in the Diagnosis and Treatment of Aneurysmal Subarachnoid Hemorrhage.- Reviews of Trials on the Effect of Oral Nimodipine on Cerebral Infarction and Outcome Following Subarachnoid Haemorrhage.- Treatment by Nimodipine of Ischemic Neurologic Deficits Due to Vasospasm.- Safety Profile of Nimodipine in Patients with Subarachnoid Hemorrhage.- Session III. Acute Ischemic Stroke.- Pathophysiology of Ischemic Brain Disease.- Positron Emission Tomography in Nimodipine-Treated Patients with Acute Ischemic Stroke.- Brain Regional Pharmacokinetics of 11C-Nimodipine in Patients with Acute Stroke: A Preliminary Account of a Positron Emission Tomographic Study.- Nimodipine and Other Calcium Antagonists in Acute Ischemic Stroke.- Pool Analysis of the European Studies of Nimodipine in Acute Ischemic Stroke.- Session IV. Cerebral Resuscitation.- Pharmacokinetics of Nimodipine in the Dog Resuscitated After Cardiopulmonary Arrest.- Plasma Concentrations of Nimodipine in Patients Resuscitated After an Out-of-Hospital Cardiac Arrest.- Influence of Nimodipine on Cerebral Blood Flow After Cardiac Arrest in Humans.- Early Effects of Nimodipine on Intracranial and Cerebral Perfusion Pressures in Cerebral Anoxia After Out-of-Hospital Cardiac Arrest.- Nimodipine in Out-of Hospital Ventricular Fibrillation: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.- Session V. Severe Head Injury.- Epidemiology of Severe Head Injury: Socio-economic Consequences of Avoidable Mortality and Morbidity.- Concussion Produces Dynamic Changes in Metabolism and Calcium Accumulation Resulting in Prolonged Neurological Deficits.- The Effect of Nimodipine Following Experimental Head Injury in Rats.- Spinal Cord Injury and the Possibilities of Treatment with Calcium Antagonists.- The Effect of Nimodipine on Outcome After Head Injury: A Prospective Randomized Controlled Trial.