Industry 4.0 is based on the cyber-physical transformation of processes, systems and methods applied in the manufacturing sector, and on its autonomous and decentralized operation. Industry 4.0 reflects that the industrial world is at the beginning of the so-called Fourth Industrial Revolution, characterized by a massive interconnection of assets and the integration of human operators with the manufacturing environment. In this regard, data analytics and, specifically, the artificial intelligence is the vehicular technology towards the next generation of smart factories.Chapters in this book cover a diversity of current and new developments in the use of artificial intelligence on the industrial sector seen from the fourth industrial revolution point of view, namely, cyber-physical applications, artificial intelligence technologies and tools, Industrial Internet of Things and data analytics. This book contains high-quality chapters containing original research results and literature review of exceptional merit. Thus, it is in the aim of the book to contribute to the literature of the topic in this regard and let the readers know current and new trends in the use of artificial intelligence for the Industry 4.0.