Cities have entered a phase where climate change is no longer a distant projection but an immediate design constraint. Flooding, heatwaves, coastal erosion, water scarcity, and ecological degradation now shape how cities must be planned, built, and maintained. Responding to these pressures requires a fundamental rethinking of urban systems. Nature-Based and Climate Responsive Design for Urban Systems explores how ecological design innovations can strengthen urban resilience and liveability while reshaping the relationship between cities and their natural environments. This book is the third volume of a trilogy examining climate-oriented design innovation in the built environment. While the earlier volumes focus on conceptual frameworks and strategic directions, this volume emphasises practical design approaches that integrate natural systems into urban infrastructure and spatial planning. Its central premise is clear: future cities must work with natural processes rather than attempt to control or resist them. Nature-based solutions, blue-green infrastructure, and climate-responsive design are therefore positioned as core components of contemporary urban systems. Through a diverse set of global case studies, the book demonstrates how ecological design strategies can address challenges such as flooding, coastal vulnerability, water management, and biodiversity loss. Examples from Nepal, Bangladesh, Vanuatu, Mexico, Madagascar, and other regions across the Pacific and Global South illustrate how nature-based approaches support environmental restoration, strengthen community participation, and enhance urban adaptability. By linking design practice with interdisciplinary research, the book contributes to the growing discourse on climate-responsive urbanism and offers practical insights for scholars, practitioners, and policymakers working toward more resilient and environmentally integrated urban futures.