Natural Killer T cells: Balancing the Regulation of Tumor Immunity: Cancer Drug Discovery and Development

Preface.-  Introduction: Mechanisms of NKT cell-mediated adjuvant activity and function of iPS-derived NKT cells.- Structure and Recognition of Antigens for Invariant NKT Cells.- Invariant NKT cell-based vaccine strategies.- Immune regulation of tumor immunity by NKT cells.- The Regulation of CD1d⁺ and CD1d^- tumors by NKT Cells.- DC-based immunotherapy targeting NKT cells.- Therapeutic Approaches Utilising NKT Cells.- NKT Cells of Cancer Patients & How Models can Inform Therapeutic Plans.- Understanding the role of Natural Killer T (NKT) cells in hematologic malignancies: progress and challenges.- Clinical trials with α-galactosylceramide (KRN7000) in advanced cancer.- Clinical trials of invariant Natural Killer T cell-based immunotherapy for cancer.- Index.  

From the reviews:
“This book is essentially a collection of reviews that introduce the reader to the wonderful world of iNKT cells, and how their powerful adjuvant properties are being utilised by different researchers. … this book is worth reading whether you are a new student in the NKT field and want to learn more or whether you are a clinician with an interest in tumour immunology.” (Salah Mansour, Immunology News, November, 2012)

Natural killer T (NKT) cells are CD1d-restricted T cells that respond to lipid, not protein, antigens presented by CD1d, which is a non-classical MHC class I-like molecule.  This relatively small but pivotal T cell population bridges the gap between innate and adaptive immunity by rapidly produce large amounts of many kinds of cytokines and by providing the T cell arm of the adaptive immune system a mechanism to detect lipid antigens. NKT cells also have both regulatory and effector functions and have been shown to play critical roles in the regulation of immune responses in many disease settings including cancer. Stimulating the protective functions of NKT cells while inhibiting the negative regulatory activity shows promise for the therapy of cancer and several approaches are in clinical trials.
 
            This book reviews what we have learned about NKT cells during last two decades through functional studies in the context of tumor immunology, including clinical trials of NKT cell targeted therapy.  This knowledge should also be informative to understand the role of this underappreciated T cell population in many other fields outside of tumor immunology.

Natural killer T (NKT) cells discussed in this book are CD1d-restricted T cells Overview of structures and functions of glycolipid antigens Explains roles of NKT cells in human lymphoma patients Includes supplementary material: sn.pub/extras