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Nanomaterials as Gene and Nucleic Acid Delivery Platforms: Woodhead Publishing Series in Biomaterials

Editat de Rocktotpal Konwarh, William C.S. Cho
en Limba Engleză Paperback – 15 sep 2026
Nanomaterials as Gene and Nucleic Acid Delivery Platforms explores the intersection between gene therapy and nanotechnology, assessing the benefits of nanoscale platforms for safe and efficient gene and nucleic acid delivery. Sections address the growing need for alternative gene delivery methods to overcome the limitations and safety concerns associated with conventional viral vectors. Four comprehensive parts provide a holistic overview of the core concepts of gene therapy and delivery; the broad range of nanomaterials available for use as carriers; key approaches, and clinical translation of nanomaterial-based delivery platforms for gene therapy.

This book will be of great use to researchers and academics in the fields of nanomaterials, biomaterials, gene therapy, molecular biology, immunology, and disease therapeutics. This book may also be of interest to clinicians researching novel materials and approaches for therapeutics.

  • Covers the unique and beneficial properties of a wide range of nanomaterials for gene and nucleic acid delivery, including polymers, proteins and peptides, lipids, metals, and carbon-based nanomaterials
  • Reviews applications of nanomaterial-based gene delivery platforms in tissue engineering, regenerative medicine, drug delivery, cancer treatment, and more
  • Details assay approaches and transfection factors for in vitro and in vivo use, as well as clinical translation considerations
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Specificații

ISBN-13: 9780443277146
ISBN-10: 0443277141
Pagini: 700
Dimensiuni: 152 x 229 mm
Editura: ELSEVIER SCIENCE
Seria Woodhead Publishing Series in Biomaterials


Cuprins

Part 1: Introduction to Nanomaterials in Gene and Nucleic Acid Delivery
1. Nanomaterials: Basics to biocargo-delivery applications
2. Gene therapy: Principles, prospects, and challenges in viral and non-viral gene delivery stratagems
3. Harnessing nanomaterials in gene delivery, gene therapy and genome engineering- Retrospect and prospects

Part 2: Spectrum of Nanomaterials for Gene Delivery
4. Design, diversity and applications of polymeric nanomaterials in gene delivery
5. Dendrimers and nanostructured hyperbranched polymers in gene delivery
6. Proteins and peptide nanomaterials for gene delivery
7. Polysaccharide based nanomaterials for gene delivery
8. Lipid based nanomaterials in gene delivery
9. Harnessing exosomes for gene delivery
10. Metal based nanomaterials in nucleic acid delivery and therapy
11. Carbon and silica-based nanomaterials for gene delivery
12. Quantum dots as multifunctional gene delivery agents
13. Trigger/stimulus-responsive nanomaterials for gene delivery
14. Viruses: Prospects for nanomedicine and gene delivery

Part 3: Approaches and Considerations in Nanomaterials Mediated Gene Delivery
15. Factors affecting in vitro and ex vivo transfection and in vivo gene delivery using nanomaterials
16. Nanomaterials and gene expression profile modulation
17. Assay approaches for in vitro and in vivo gene expression profiling
18. Nanotechnology, omics science and gene therapy
19. Nanomaterials and facets of epigenetics

Part 4: Key Applications and Clinical Translation
20. Plant genome engineering: Prospects of nanomaterials-based gene delivery
21. Gene delivery using electrospun nanobiomaterials: Implications in tissue engineering and regenerative medicine
22. Nanomaterials for siRNA delivery and the gamut of applications
23. Nanomaterials as CRISPR/Cas delivery platforms for genome editing
24. Harnessing nanomaterials in gene therapy for cancer
25. Nanomaterials for neural-specific gene therapy
26. Nanotechnology in gene delivery for ophthalmic applications
27. Ethics, clinical translation and safety regulations of nanomaterials in gene therapy