Research Paper (postgraduate) from the year 2017 in the subject Biology - Miscellaneous, grade: 3.00, course: biotechnology, language: English, abstract: The successful in developing a straightforward preparative route in biomaterial composite fabrication with the great promising Umbilical Cord Matrix derived mesenchymal stem cells (MSCs) known as Wharton's Jelly also well known as fetal MSC. WJMSC has been created a reliable modernist and briskest innovative research method especially in manipulation of Graphene Oxide (GO) as a new biomaterials loaded with an ample advantages in regard of synthetic materials that applicable for a replacement or regenerating a living system. Bio-interface in mesenchymal stem cell certainly brighten the hope of all stripes scientist researchers in aspiration of biomaterial application whilst can impact the benefit in the fields of biomedical, biotechnology, bioengineering, pharmacology and biosensors yet the finding remain a number of challenges in the fast-growing field. The purpose of this review, we enumerated the key aspect an earmark that will be focused on GO functionalization, and GO-WJMSC characterization, accordingly to GO-WJMSC application in enhanced the proliferation, and multipotency for a brighter future potential of GO-stem cells applicability.