Metal Complex - DNA Interactions
Editat de Nick Hadjiliadis, Einar Slettenen Limba Engleză Hardback – mai 2009
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Specificații
ISBN-13: 9781405176293
ISBN-10: 1405176296
Pagini: 544
Dimensiuni: 173 x 249 x 36 mm
Greutate: 1.07 kg
Ediția:New.
Editura: Wiley
Locul publicării:Chichester, United Kingdom
ISBN-10: 1405176296
Pagini: 544
Dimensiuni: 173 x 249 x 36 mm
Greutate: 1.07 kg
Ediția:New.
Editura: Wiley
Locul publicării:Chichester, United Kingdom
Public țintă
Researchers in bioinorganic chemistry, biochemistry, biology and medicine. Industrial pharmaceutical chemists, particularly those involved in developing metal–based drugs.Cuprins
A Basic Structural and Kinetic Aspects1. Sequence-Selective Binding of Transition Metal Complexes to DNA
2. Thermodynamic Models of Metal Ion -DNA.Interactions
3. Metal Ion Coordination in G-quadruplexes
4. Supramolecular Chemistry of Metal-Nucleobase Complexes
B Medical Applications
5. Platinum Drugs, Nucleotides, and DNA: the Role of Interligand Interactions,
nucleotides and DNA
6. Role of DNA Repair in Antitumor Effects of Platinum Drugs
7. Telomeres and Telomerase: Potential Targets for Platinum Complexes
8. Toward Photodynamic Therapy of Cancer with Platinum Group Metal Polyazine Complexes
9. Platinated Oligonucleotides: Synthesis and Applications for the Control of Gene
Expression
10. New Titanium and Ruthenium Anticancer Drugs and their Interaction with DNA
C DNA-Recognition - Nucleases and Sensors
11. Groove-Binding Ruthenium(II) Complexes as Probes of DNA Recognition
12. DNA Recognition and Binding by Peptide-Metal Complex conjugate
13. Artificial Restriction Agents - Hydrolytic Agents for DNA Cleavage
14. New Metallo-DNAzymes: Fundamental Studies of Metal-DNA Interactions and
Metal Sensing Applications
15. Two-metal Ion Dependent Catalysis in Nucleic Acid Enzymes
D Toxicological aspects
16. Mercury- DNA Interactions. Structural Studies on MercuryII -Mediated T-T Base-Pair with NMR Spectroscopy
17. Chromium-Induced DNA Damage and Repair
18. Arsenic and nickel: Mechanisms Affecting DNA Integrity
2. Thermodynamic Models of Metal Ion -DNA.Interactions
3. Metal Ion Coordination in G-quadruplexes
4. Supramolecular Chemistry of Metal-Nucleobase Complexes
B Medical Applications
5. Platinum Drugs, Nucleotides, and DNA: the Role of Interligand Interactions,
nucleotides and DNA
6. Role of DNA Repair in Antitumor Effects of Platinum Drugs
7. Telomeres and Telomerase: Potential Targets for Platinum Complexes
8. Toward Photodynamic Therapy of Cancer with Platinum Group Metal Polyazine Complexes
9. Platinated Oligonucleotides: Synthesis and Applications for the Control of Gene
Expression
10. New Titanium and Ruthenium Anticancer Drugs and their Interaction with DNA
C DNA-Recognition - Nucleases and Sensors
11. Groove-Binding Ruthenium(II) Complexes as Probes of DNA Recognition
12. DNA Recognition and Binding by Peptide-Metal Complex conjugate
13. Artificial Restriction Agents - Hydrolytic Agents for DNA Cleavage
14. New Metallo-DNAzymes: Fundamental Studies of Metal-DNA Interactions and
Metal Sensing Applications
15. Two-metal Ion Dependent Catalysis in Nucleic Acid Enzymes
D Toxicological aspects
16. Mercury- DNA Interactions. Structural Studies on MercuryII -Mediated T-T Base-Pair with NMR Spectroscopy
17. Chromium-Induced DNA Damage and Repair
18. Arsenic and nickel: Mechanisms Affecting DNA Integrity