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Metabolic Syndrome de Akhlaq A. Farooqui

Metabolic Syndrome

Autor Akhlaq A. Farooqui
en Limba Engleză Hardback – 14 iun 2013
Metabolic syndrome as an important risk factor for stroke, Alzheimer disease, and depression presents readers with cutting edge and comprehensive information on relationship among metabolic syndrome, stroke, Alzheimer disease, and depression. It is hoped that this monograph will be useful to postgraduate students, faculty, research scientists, pharmacologists, nutritionists, and physicians, who are curious about the molecular mechanisms that link metabolic syndrome with stroke, Alzheimer disease, and depression.
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Specificații

ISBN-13: 9781461473176
ISBN-10: 1461473179
Pagini: 432
Ilustrații: XX, 412 p.
Dimensiuni: 160 x 241 x 29 mm
Greutate: 0.76 kg
Ediția:2013
Editura: Springer
Locul publicării:New York, NY, United States

Public țintă

Research

Cuprins

Chapter 1:The effect of unhealthy lifestyle on brain metabolism and function.- Chapter 2: The effect of metabolic syndrome on the brain.- Chapter 3: The Association of essential fatty acid metabolism in the pathogenesis of metabolic syndrome and neurological disorders.- Chapter 4: Contribution of lipid mediators to the pathogenesis of metabolic syndrome and neurological disorders.- Chapter 5: Molecular aspects of obesity and insulin resistance in metabolic syndrome and neurological disorders.- Chapter 6: Dietary interventions of metabolic syndrome and neurological disorders.- Chapter 7: Signal transduction processes and metabolic link among metabolic syndrome and stroke.- Chapter 8: Signal transduction processes and metabolic link among metabolic syndrome and Alzheimer’s disease.- Chapter 9: Signal transduction processes and metabolic link among metabolic syndrome and depression.- Chapter 10: Future research perspectives​.

Textul de pe ultima copertă

The metabolic syndrome is a cluster of common pathologies: abdominal obesity linked to an excess of visceral fat, insulin resistance, dyslipidemia and hypertension. At the molecular level, metabolic syndrome is accompanied not only by dysregulation in the expression of adipokines, cytokines, and chemokines but also by alterations in insulin and leptin signaling, oxidative stress, and chronic low grade inflammation. These changes affect immune responses and mediate chronic inflammation leading to alterations in the hypothalamic ‘bodyweight/appetite/satiety set point’. It is becoming increasingly evident that metabolic syndrome is a risk factor for neurological disorders such as stroke, depression, and Alzheimer disease (AD). Family history, age, environmental and lifestyle factors (diet and physical inactivity, and exposure to toxins) are closely associated with predisposition for the development of metabolic syndrome as well as neurological disorders. The incidences of stroke are 2 to 4-fold higher in patients with metabolic syndrome and cardiovascular diseases compared to normal subjects of the same age. Similarly, patients with metabolic syndrome have a 2 to 3-fold increased risk for developing dementia and AD. Metabolic syndrome doubles the risk of depression. The molecular mechanism underlying the mirror relationship between metabolic syndrome and neurological disorders is not fully understood. However, biochemical alterations observed in metabolic syndrome like induction of chronic inflammation and oxidative stress, impairment of endothelial cell function, induction of insulin and leptin resistance, hyperglycemia-related increase in advanced glycation end-products, and micro-vascular injury may represent a pathological bridge between metabolic syndrome and neurological disorders.
It is hoped that Metabolic Syndrome: An important risk factor for stroke, Alzheimer disease, and depression will be useful to postgraduate students, faculty, research scientists, pharmacologists, nutritionists, and physicians, who are curious about the molecular mechanisms that link metabolic syndrome with stroke, Alzheimer disease, and depression.

Caracteristici

Provides a comprehensive description of signal transduction processes associated with the relationship between metabolic syndrome and neurological disorders Useful for understanding molecular aspects of metabolic syndrome and its relationship with neurological disorders Can be used as supplement text for a range of neuroscience and biochemistry courses Includes supplementary material: sn.pub/extras

Notă biografică

Dr. Akhlaq A. Farooqui is a leader in the field of brain phospholipases A2, bioactive ether lipid metabolism, polyunsaturated fatty acid metabolism, glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators, glutamate-induced neurotoxicity and neurological disorders. He has discovered the stimulation of plasmalogen-selective phospholipase A2 (PlsEtn-PLA2) in brains from patients with Alzheimer disease. Stimulation of PlsEtn-PLA2 produces plasmalogen deficiency and increases levels of eicosanoids that may be related to the loss of synapses, induction of neuroinflammation and oxidative stress in brains of patients with Alzheimer disease. Dr. Farooqui has published cutting edge research on the generation and identification of glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators in kainic acid neurotoxicity by lipidomics. He has previously authored five monographs: Glycerophospholipids in Brain: Phospholipase A2 in Neurological Disorders (2007); Neurochemical Aspects of Excitotoxicity (2008); Metabolism and Functions of Bioactive Ether Lipids in Brain (2008); Hot Topics in Neural Membrane Lipidology (2009), and Beneficial Effects of Fish Oil on Human Brain (2009). All monographs are published by Springer. Dr. Farooqui has also edited two books: "Biogenic Amines: Pharmacological, Neurochemical and Molecular Aspects in the CNS" Nova Science Publishers, Hauppauge, N.Y (2010) and Molecular Aspects of Neurodegeneration and Neuroprotection, Bentham Science Publishers Ltd (2010).