In this issue of Dermatologic Clinics, guest editors Drs. Darrell S. Rigel, Joshua Burshtein, Milaan Shah, and Danny Zakria bring their considerable expertise to the topic of Melanoma and Pigmented Lesion Update. Top experts in the field discuss trends in melanoma incidence and mortality; risk factors for primary cutaneous melanoma; lesional markers and precursors of melanoma; histopathology of melanoma; AI in melanoma: diagnosis and management; and more.