In this issue of Urologic Clinics of North America, guest editor Dr. Isaac Yi Kim brings his considerable expertise to the topic of Management of Advanced and Metastatic Prostate Cancer. Although prostate cancer is generally considered curable, advanced and metastatic prostate cancer remain a challenge for urologists and oncologists. In this issue, top experts discuss pelvic lymph node dissection; radiotherapy for high-risk prostate cancer; managing clinical N1 prostate cancer; managing biochemical recurrence after definitive local therapy; and more.