Leatherface: A Tale of Old Flanders begins in 1572, with Spain holding sway over Flanders with an absolute monarchy. People are held in a state of fear by their conquerors due to the threat of the Inquisition and its tortures. The plot opens with the Prince of Orange, William, who is currently a wanted man, hiding out in the city of Ghent after leading a failed rebellion. His cunning and faithful watchdog, a mysterious man called Leatherface for the mask he wears, is the only reason Orange is still alive. By arranging for the marriage of his general's daughter Lenora to Ghent's High Bailiff's son, the Spanish Duke of Alva devises a scheme to assassinate Orange by inserting a spy into a household that is known to support Orange. Will they succeed or will Leatherface be able to thwart their plans?