This book aims at bringing together academic and industry, researchers in mechanical engineering and their worldwide partners in a stimulating environment. ISIEA is an annual event that takes place in Bolzano and is organized by the Industrial Engineering and Automation macro-area of the Free University of Bozen/Bolzano. The main theme of the 2024 edition covers all major areas of R&D and innovation in advanced mechanical engineering. Special sessions on tribology and materials, modeling and simulations, powertrains, applied mechanics and robotics have been presented. Special track related to life and efficiency of bearings; cycloidal speed reducers; multi-physics modeling approaches; infrared thermography; planning and control of robotic and mechatronic systems; mobile field robotics; formulations and applications of structural and multibody dynamics; innovative solutions for safer and more sustainable mobility; artificial intelligence in manufacturing and mechanical engineering; advancements in aerospace technologies; innovative engineering education; SME 5.0: intelligent, sustainable and human-centered SMEs have been presented.