Judaism and Science canvases three millennia of Jewish attitudes towards nature and its study. It answers many questions about the complex relationship of religion and science. How did religious attitudes and dogmas affect Jewish attitudes towards natural knowledge? How was Jewish interest in science reflected, and was facilitated by, links with other cultures - Egypt and Assyria and Babylon in ancient times, Moslem culture in medieval times, and Christian culture during the Renaissance and since? How did science serve as a bridge between religious communities that were otherwise estranged and embattled? How did science serve as a vehicle of assimilation into the wider intellectual culture in which Jews found themselves? The book considers the attitudes and work of particular Jews in different epochs. It takes an eagle's-eye view of its subject, considering broad themes from a high vantage, but also swooping down to consider particular individuals at high focus, and in detail.

Judaism and Science encompasses the entire history of the interaction of Jews and natural knowledge.
; Part I: The Sages of Israel and Natural Wisdom describes the images of nature and natural philosophy in the two most important sets of books on the Jewish bookshelf: the Biblical corpus and the Talmudic/Early Rabbinic corpus
; Part II: Jews and Natural Philosophy shows how Jews explained nature, especially the nature of the heavens, or astronomy and astrology, in medieval times and early modern times.
; Part III: Jews and Science - describes the entry of Jews into modern science, beginning in 19th century Europe and 20th century United States, USSR and Israel, emphasizing the social background of the rapid entry of Jews into modern sciences, and of their remarkable successes.
; The volume includes annotated primary source documents, a timeline of important events, and an bibliography of essential primary and secondary sources for further research.