Simulation-Based Engineering and Science (SBE&S) cuts across disciplines, showing tremendous promise in areas from storm prediction and climate modeling to understanding the brain and the behavior of numerous other complex systems.In this groundbreaking volume, nine distinguished leaders assess the latest research trends, as a result of 52 site visits in Europe and Asia and hundreds of hours of expert interviews, and discuss the implications of their findings for the US government.The authors conclude that while the US remains the quantitative leader in SBE&S research and development, it is very much in danger of losing that edge to Europe and Asia.Commissioned by the National Science Foundation, this multifaceted study will capture the attention of Fortune 500 companies and policymakers.Distinguished contributors: Sharon C Goltzer, University of Michigan, Ann Arbor, USASangtae Kim, Morgridge Institute for Research, USAPeter T Cummings, Vanderbilt University, USA and Oak Ridge National Laboratory, USAAbhijit Deshmukh, Texas A&M University, USAMartin Head-Gordon, University of California, Berkeley, USAGeorge Em Karniadakis, Brown University, USALinda Petzold, University of California, Santa Barbara, USACeleste Sagui, North Carolina State University, USAMasanobu Shinozuka, University of California, Irvine, USA