This book consists of contributions made by renowned clinicians as well as scientists from growing integrative fields of research regarding the clinical and molecular features of insulin resistance. The aim of this book is to encourage scientists and physicians - engaged separately on several distinct aspects of insulin resistance and metabolic syndrome for early diagnosis of the first signs signifying the onset of a metabolic misbalance in order to prevent the consecutive cascades which lead to metabolic syndrome, resulting in the so-called diseases like hypertension, diabetes and cancer. Several metabolic disturbances related to insulin resistance are also explained in this book like adipokines, tissue-specific defects in insulin action and signaling, ectopic lipid deposition, inflammatory cytokines, endothelial dysfunction, oxidative stress and disordered neuroregulation.