This book addresses those involved in research or R&D. It introduces the principles of eco-innovation and the importance of the impact of their activity. This topic is considered in the context of natural and digital ecosystems powered by intelligent assistants (technology). Chapter 1 positions the innovation as a process and component of ecosystems including research, enterprises, technology (digital ecosystems) and environment. Sustainable success is a condition of survival and an expectation of those who invest in innovation. Chapter 2 describes the main elements to consider and gives some tips. Chapter 3 presents some selected initiatives at the national and European level and provides a way of measuring success.