This book constitutes the refereed proceedings of the 28th International Conference on Information and Software Technologies, ICIST 2022, held in Kaunas, Lithuania, in October 2022. The 23 full papers and 3 short papers presented were carefully reviewed and selected from 66 submissions. The papers discuss such topics as ​business intelligence for information and software systems, intelligent methods for data analysis and computer aided software engineering, information technology applications, smart e-learning technologies and applications, language technologies.