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Inflammation: the Common Link in Brain Pathologies de Nihar Jana

Inflammation: the Common Link in Brain Pathologies

Editat de Nihar Jana, Anirban Basu, Prakash Narain Tandon
en Limba Engleză Hardback – 22 aug 2016

Observăm în volumul Inflammation: the Common Link in Brain Pathologies, prima ediție publicată de Springer, o tentativă ambițioasă de a unifica cercetările recente despre interacțiunea dintre sistemul imunitar și cel nervos. Spre deosebire de abordările fragmentate, această lucrare propune inflamația ca numitor comun pentru o gamă largă de afecțiuni neurologice. Notăm cu interes includerea unor capitole ce depășesc sfera clasică a neurodegenerării, precum legătura dintre obezitate și neuroinflamație sau patologiile retiniene, oferind o perspectivă sistemică asupra sănătății cerebrale.

Lucrarea extinde cadrul propus de Neuroinflammation and Neurodegeneration de Phillip K. Peterson prin integrarea unor date noi privind mecanismele moleculare ale astrocitelor și microgliei în contextul infecțiilor sistemului nervos. În timp ce titluri precum Neuroinflammation de Alireza Minagar se concentrează pe afecțiuni demielinizante specifice, volumul de față, editat de Nihar Jana, Anirban Basu și Prakash Narain Tandon, prioritizează mecanismele fiziopatologice fundamentale care preced diagnosticul clinic.

Structura este organizată riguros în zece capitole, debutând cu fiziologia generală a celulelor gliale și progresând spre studii de caz clinice. Cuprinsul indică o trecere logică de la biologia celulară (capitolele 1-2) la patologii neurodegenerative (Huntington, Parkinson), urmate de afecțiuni acute (accident vascular cerebral) și influența factorilor metabolici. Această progresie permite cititorului să înțeleagă cum mediatori inflamatori similari pot genera manifestări clinice atât de variate, de la neurodegenerare la oncologie cerebrală.

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Specificații

ISBN-13: 9789811017100
ISBN-10: 9811017107
Pagini: 460
Ilustrații: X, 345 p. 38 illus., 31 illus. in color.
Dimensiuni: 155 x 235 x 24 mm
Greutate: 0.81 kg
Ediția:1st ed. 2016
Editura: Springer Nature Singapore
Colecția Springer
Locul publicării:Singapore, Singapore

De ce să citești această carte

Această lucrare este esențială pentru cercetătorii și clinicienii care doresc să înțeleagă neuroimunologia dincolo de granițele unei singure patologii. Cititorul câștigă o viziune de ansamblu asupra modului în care inflamația mediază tulburările cerebrale, beneficiind de expertiza multidisciplinară a unor lideri în domeniu. Este un instrument valoros pentru cei care dezvoltă noi strategii terapeutice în neurofarmacologie, oferind baze teoretice solide pentru intervenția în procesele inflamatorii.

Despre autor

Volumul este coordonat de o echipă de experți de renume, sub îndrumarea profesorului Prakash Narain Tandon, o figură marcantă în neuroștiințele internaționale, cunoscut pentru contribuțiile sale la dezvoltarea neurochirurgiei și cercetării creierului. Alături de el, Nihar Jana și Anirban Basu aduc o expertiză vastă în neurobiologie moleculară și neurovirologie. Colectivul de editori reflectă caracterul multidisciplinar al cărții, aceștia activând în instituții de prestigiu unde studiază intersecția dintre răspunsul imun și integritatea neuronală, contribuind constant la literatura de specialitate prin studii asupra mecanismelor de apărare ale sistemului nervos central.

Descriere scurtă

This unifying theme of this book-with sections on mechanisms of defense and neuropathogenesis, neurological diseases, infections of the nervous system, neuropharmacology, and novel therapies-is interactions of the immune and nervous systems. It also discusses the role of inflammation as a key mediator of different brain disorders. There have been significant scientific advances in the multidisciplinary field of neuroimmunology / neuroinflammation in the past decade, and this book, edited under the guidance of Professor P. N. Tandon, fosters communication between those who share an interest in this exciting area, including neuroscientists, immunologists, cell biologists, clinicians and neuropharmacologists.

Cuprins

1. Chapter 1. General Physiology and Pathophysiology of Microglia in inflammation.- Chapter 2. Inflammation and the Pathophysiology of Astrocytes in brain disorders.- Chapter 3. Neuroinflammation in Huntington’s and related neurodegenerative disorders.- Chapter 4. Brain infection and inflammation.- Chapter 5. Neuroinflammation in Ischemic Stroke.- Chapter 6. Innate and Adaptive Immune-Mediated Neuroinflammation in Parkinson’s Disease.- Chapter 7. Brain cancer and inflammation.- Chapter 8. Demylinating diseases and neuro-inflammation.- Chapter 9. Obesity and neuro-inflammation.- Chapter 10. Retinal disorder/degeneration and inflammation associated with it.

Notă biografică

Dr. Nihar Ranjan Jana presently working as Professor at National Brain Research Centre (NBRC), Manesar. Dr. Jana obtained his Ph.D. from Visva-Bharati University in 1996.  After completing his Post Doctoral training at RIKEN Brain Science Institute, Japan, he joined NBRC in 2001. His laboratory is primarily interested in exploring the role of ubiquitin ligases in cellular protein quality control and how loss of function of quality control ubiquitin ligases lead to neuronal dysfunction or neurodegeneration observed in various neurological disorders. Dr. Jana is elected fellow of National Academy of Sciences, India (2008) and West Bengal Academy of Science and Technology (2012). He is a recipient National Bioscience Award (2008, DBT) and TATA Innovation Fellowship (2014, DBT), VASVIK award (2012) and KT Shetty memorial award (2013 from Indian Academy of Neurosciences). Currently, he is serving as an editorial board member of PLOS ONE, Frontier of Molecular Neurosciences and Annals ofNeurosciences. 
Anirban Basu is a Senior Scientist and Additional Professor at National Brain Research Center, Manesar, Haryana. He received his Ph.D. degree in Immunology from the Indian Institute of Chemical Biology, Kolkata. He then obtained Postdoctoral training in Neuro-immunology at Neural and Behavioral Science Dept at Pennsylvania State University College of Medicine, US. So far he has trained 4 Masters students, 9 PhD students and 9 postdocs, and numerous short term and long term research trainees in his lab. Dr. Basu has long been interested in curing diseases of the nervous system. His current research is focused on identifying the role of microglia and neural stem/progenitor cells in the healthy and diseased central nervous system, with specific reference to CNS infections, and neurodegenerative diseases. The group of students who currently work with him is testing strategies to develop disease modifying therapy by abrogating inflammation in CNS disorders. Dr Basu is the recipient of National Bioscience Award for Career Development (2010), Vasvik Industrial Research Award (2011), Dr. J.B. Srivastav Oration Award (2011), Rajib Goyal Prize (2012) and NASI- Reliance Industries Platinum Jubilee Award (2013), Tata Innovation Fellowship (2015) from the Department of Biotechnology, and Senior Scientist Oration Award (2015) from the Indian Immunology Society. He is also an elected Fellow of the National Academy of Sciences, India and West Bengal Academy of Science and Technology. Dr Basu sits on the editorial boards of the Journal of Neurochemistry, Scientific Reports, Journal of Neuroinflammation, PLoS One, Frontiers in Molecular Neuroscience, and Metabolic Brain Diseases. He is also a faculty member in the Faculty of 1000 in the section Neurological Disorders.

Prakash Narain Tandon National Research Professor and President of National Brain Research Centre Society, Manesar, Gurgaon-122051
Residential Address: House No. 1, Jagriti Enclave, Vikash Marg Extension, New Delhi, Tel: 011-22163272
Date of birth: 13 August 1928. 
He has graduated with an MBBS and MS from the University of Lucknow in 1950 and 52 respectively.
Trained at the University of London and obtained his FRCS in 1956. 
He further obtained his specialist training in neurosurgery at Oslo, Norway and Montreal, Canada. 
After a brief tenure as a professor at the K.G. Medical College, Lucknow (1963–65), he moved to the prestigious All India Institute of Medical Sciences, New Delhi where he founded the neurosurgery department where he has been a professor of neurosurgery.
He received Bhatnagar award (CSIR), fellow of the National Academy of Medical Sciences and Indian National Science Academy, He also served as President of Indian National Science Academy in 1991-92.
He been awarded Padma Shri (1973) and Padma Bhushan (1991) by the Government of India.

 
 
 
   
 
   

Caracteristici

Includes chapters that are a state-of-the art mini-reviews Reviews the role of inflammation as a key mediator of different brain disorders Covers multiple disorders in one volume Written by contributors who are leading experts of their respective fields Includes supplementary material: sn.pub/extras