In the year 269 of the Second Age, the ancient port city of New Orleans is still steeped in voodoo rituals and overrun with vampires, vengeful spirits, werewolves and other things that haunt the darkness. Unable to cope with this worsening situation, Voodoo Queen Minerva DuPree sends an urgent plea for help to the secretive organization known as The Vatican. Enter the enigmatic Hunter, their top Slayer, and his beautiful vampire partner, Lorena. They must not only destroy the creatures of the night but also uncover who or what is responsible for New Orleans' nightmare...