This book constitutes revised selected papers of the 7th Latin American High Performance Computing Conference, CARLA 2020, held in Cuenca, Ecuador, in September 2020. Due to the COVID-19 pandemic the conference was held in a virtual mode.  The 15 revised full papers presented were carefully reviewed and selected out of 36 submissions. The papers included in this book are organized according to the topics on ​High Performance Computing Applications; High Performance Computing and Artificial Intelligence.